Immunological synapse formation inhibits, via NF-κB and FOXO1, the apoptosis of dendritic cells

被引：65

作者：

Riol-Blanco, Lorena ^{[1
]}

Delgado-Martin, Cristina ^{[1
]}

Sanchez-Sanchez, Noelia ^{[1
]}

Alonso-C, Luis M. ^{[2
]}

Dolores Gutierrez-Lopez, Maria ^{[3
]}

Martinez del Hoyo, Gloria ^{[4
]}

Navarro, Joaquin ^{[5
]}

Sanchez-Madrid, Francisco ^{[4
,6
]}

Cabanas, Carlos ^{[3
]}

Sanchez-Mateos, Paloma ^{[5
]}

Luis Rodriguez-Fernandez, Jose ^{[1
]}

机构：

[1] CSIC, Ctr Invest Biol, Madrid, Spain

[2] Univ Complutense, Ctr Microscopia & Citometria, E-28040 Madrid, Spain

[3] CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain

[4] Univ Autonoma Madrid, Hosp La Princesa, Serv Inmunol, Madrid, Spain

[5] Hosp Gen Gregorio Maranon, Lab Inmunooncol, Madrid, Spain

[6] Ctr Nacl Invest Cardiovasc, Dept Biol Vasc & Inflamac, Madrid, Spain

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 07期

关键词：

LYMPH-NODES; T-CELLS; IN-VIVO; ANTIGEN RECOGNITION; LIFE-SPAN; ACTIVATION; BINDING; DEATH; LYMPHOCYTES; MOLECULES;

D O I：

10.1038/ni.1750

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunological synapse (IS) is a cell-cell junction formed between CD4(+) T cells and dendritic cells (DCs). Here we show in vitro and in vivo that IS formation inhibits apoptosis of DCs. Consistent with these results, IS formation induced antiapoptotic signaling events, including activation of the kinase Akt1 and localization of the prosurvival transcription factor NF-kappa B and the proapoptotic transcription factor FOXO1 to the nucleus and cytoplasm, respectively. Inhibition of phosphatidylinositol 3-OH kinase and Akt1 partially prevented the antiapoptotic effects of IS formation. Direct stimulation of the IS component CD40 on DCs leads to the activation of Akt1, suggesting the involvement of this receptor in the antiapoptotic effects observed upon IS formation.

引用

页码：753 / U110

页数：10

共 51 条

[1] Cutting edge: The dendritic cell cytoskeleton is critical for the formation of the immunological synapse [J].