Ugi/Himbert Arene/Allene Diels-Alder Cycloaddition to Synthesize Strained Polycyclic Skeleton

被引：36

作者：

Cheng, Guangsheng ^{[1
]}

He, Xiang ^{[1
]}

Tian, Lumin ^{[1
]}

Chen, Jiawen ^{[1
]}

Li, Chunju ^{[1
]}

Jia, Xueshun ^{[1
,2
]}

Li, Jian ^{[1
]}

机构：

[1] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 21期

基金：

中国国家自然科学基金;

关键词：

MULTICOMPONENT REACTIONS; OLIGOSUBSTITUTED PYRROLES; SPIROCYCLIC OXINDOLES; MOLECULAR COMPLEXITY; ISOCYANIDE INSERTION; CONCISE SYNTHESIS; RAPID ACCESS; ALLENECARBOXANILIDES; REARRANGEMENT; SUBSTITUENTS;

D O I：

10.1021/acs.joc.5b01724

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The present work disclosed an efficient multicomponent reaction of isocyanide, allenic acid, aldehyde (ketone), and aniline. This protocol undergoes Ugi reaction followed by an intramolecular arene/allene Diels-Alder sequence, thus providing a rapid access to synthesize strained polycyclic skeletons.

引用

页码：11100 / 11107

页数：8

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