Klotho, a new marker for osteoporosis and muscle strength in β-thalassemia major

被引:28
作者
Baldan, Alessandro [1 ,5 ]
Giusti, Andrea [2 ]
Bosi, Cristina [3 ]
Malaventura, Cristina [1 ]
Musso, Marco [4 ]
Forni, Gian Luca [4 ]
Volpato, Stefano [3 ]
Zuliani, Giovanni [3 ]
Borgna-Pignatti, Caterina [1 ]
机构
[1] Univ Ferrara, Dept Med Sci, Sect Pediat, I-44124 Ferrara, Italy
[2] Galliera Hosp, Dept Gerontol & Musculoskeletal Sci, Bone Clin, Genoa, Italy
[3] Univ Ferrara, Dept Med Sci, Sect Internal & Cardioresp Med, I-44124 Ferrara, Italy
[4] Galliera Hosp, Ctr Microcitemia & Congenital Anemias, Genoa, Italy
[5] Univ Verona, Dept Life & Reprod Sci, Sect Biol & Genet, I-37100 Verona, Italy
关键词
beta-Thalassemia major; Osteoporosis; Fragility fractures; Klotho; Hand-grip strength; COMMUNITY-DWELLING ADULTS; PLASMA KLOTHO; ENDOTHELIAL DYSFUNCTION; PROTEIN; RISK; ABNORMALITIES; COMPLICATIONS; TRANSFUSION; HYPERTROPHY; HOMEOSTASIS;
D O I
10.1016/j.bcmd.2015.08.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim of this study was to compare plasma levels of the secreted protein Klotho in beta-thalassemia major patients and in healthy controls. Also, we examined the existence of correlations between the protein level and osteoporosis, poor muscle strength and fractures. A total of 106 patients with beta-thalassemia major and 95 healthy blood donors were enrolled. Klotho level in plasma was measured by mean of an ELISA test and the hand-grip strength using a dynamometer. Intact parathyroid hormone (PTH), 25-hydroxy vitamin D (Vitamin D), serum calcium (Ca), phosphate (P), total alkaline phosphatase (ALP), ferritin, creatinine were measured by standard clinical techniques. DXA was used to measure bone mineral density (BMD) at the lumbar spine (L2-L4), femoral neck and total hip. We found that the Klotho protein concentration was lower in the blood of patients with beta-thalassemia major than in healthy controls, and it was directly correlated to the hand-grip strength. In beta-thalassemia major patients, the secreted Klotho was lower than in healthy controls. The preliminary investigation into the correlation between markers of osteo- and sarco-penia and Klotho demonstrated a decreased Klotho concentration in beta-TM patients and a higher probability of having had fragility fractures. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:396 / 401
页数:6
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