Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application

被引：212

作者：

Zhao, Yuyun ^{[1
]}

Ye, Chunjie ^{[1
,2
]}

Liu, Wenwen ^{[1
]}

Chen, Rong ^{[2
]}

Jiang, Xingyu ^{[1
]}

机构：

[1] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China

[2] Wuhan Inst Technol, Wuhan 430073, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 31期

基金：

美国国家科学基金会; 北京市自然科学基金;

关键词：

bacteria; bimetallic nanoparticles; gold; platinum; GOLD NANOPARTICLES; ESCHERICHIA-COLI; CELLULAR ATP; MECHANISMS; OXIDATION; CATALYSTS; ANTIBIOTICS; INFECTIONS; REDUCTION; BACTERIA;

D O I：

10.1002/anie.201401035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities. The most potent antibacterial AuPt NPs happen to be the most effective catalysts for chemical transformations. The mechanism of antibiotic action includes the dissipation of membrane potential and the elevation of adenosine triphosphate (ATP) levels. These bimetallic NPs are unique in that they do not produce reactive oxygen species as most antibiotics do. Being non-toxic to human cells, these bimetallic noble NPs might open an entry to a new class of antibiotics.

引用

收藏

页码：8127 / 8131

页数：5

相关论文

共 44 条

[1] Molecular mechanisms of antibacterial multidrug resistance [J].

Alekshun, Michael N. ;

Levy, Stuart B. .

CELL, 2007, 128 (06) :1037-1050

[2] Selective Oxidation of Glycerol by Highly Active Bimetallic Catalysts at Ambient Temperature under Base-Free Conditions [J].

Brett, Gemma L. ;

He, Qian ;

Hammond, Ceri ;

Miedziak, Peter J. ;

Dimitratos, Nikolaos ;

Sankar, Meenakshisundaram ;

Herzing, Andrew A. ;

Conte, Marco ;

Lopez-Sanchez, Jose Antonio ;

Kiely, Christopher J. ;

Knight, David W. ;

Taylor, Stuart H. ;

Hutchings, Graham J. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (43) :10136-10139

[3]

Chernousova S., 2013, ANGEW CHEM, V125, P1678

[4] Mono- and bimetallic catalysts for glucose oxidation [J].

Comotti, Massimiliano ;

Della Pina, Cristina ;

Rossi, Michele .

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2006, 251 (1-2) :89-92

[5] Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites [J].

Coutinho-Silva, Robson ;

Ojcius, David M. .

MICROBES AND INFECTION, 2012, 14 (14) :1271-1277

[6] The molecular mechanism of action of bactericidal gold nanoparticles on Escherichia coli [J].

Cui, Yan ;

Zhao, Yuyun ;

Tian, Yue ;

Zhang, Wei ;

Lu, Xiaoying ;

Jiang, Xingyu .

BIOMATERIALS, 2012, 33 (07) :2327-2333

[7] Electrocatalyst approaches and challenges for automotive fuel cells [J].

Debe, Mark K. .

NATURE, 2012, 486 (7401) :43-51

[8] Nanoalloys: From theory to applications of alloy clusters and nanoparticles [J].

Ferrando, Riccardo ;

Jellinek, Julius ;

Johnston, Roy L. .

CHEMICAL REVIEWS, 2008, 108 (03) :845-910

[9] The importance of bactericidal drugs: Future directions in infectious disease [J].

Finberg, RW ;

Moellering, RC ;

Tally, FP ;

Craig, WA ;

Pankey, GA ;

Dellinger, EP ;

West, MA ;

Joshi, M ;

Linden, PK ;

Rolston, KV ;

Rotschafer, JC ;

Rybak, MJ .

CLINICAL INFECTIOUS DISEASES, 2004, 39 (09) :1314-1320

[10] Presenting vancomycin on nanoparticles to enhance antimicrobial activities [J].

Gu, HW ;

Ho, PL ;

Tong, E ;

Wang, L ;

Xu, B .

NANO LETTERS, 2003, 3 (09) :1261-1263

← 1 2 3 4 5 →