Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application

被引：202
|
作者：
Zhao, Yuyun [1 ]
Ye, Chunjie [1 ,2 ]
Liu, Wenwen [1 ]
Chen, Rong [2 ]
Jiang, Xingyu [1 ]
机构：
[1] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China
[2] Wuhan Inst Technol, Wuhan 430073, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 31期
基金：
北京市自然科学基金; 美国国家科学基金会;
关键词：
bacteria; bimetallic nanoparticles; gold; platinum; GOLD NANOPARTICLES; ESCHERICHIA-COLI; CELLULAR ATP; MECHANISMS; OXIDATION; CATALYSTS; ANTIBIOTICS; INFECTIONS; REDUCTION; BACTERIA;
D O I：
10.1002/anie.201401035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities. The most potent antibacterial AuPt NPs happen to be the most effective catalysts for chemical transformations. The mechanism of antibiotic action includes the dissipation of membrane potential and the elevation of adenosine triphosphate (ATP) levels. These bimetallic NPs are unique in that they do not produce reactive oxygen species as most antibiotics do. Being non-toxic to human cells, these bimetallic noble NPs might open an entry to a new class of antibiotics.
引用
收藏
页码：8127 / 8131
页数：5
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