Taste performance in Parkinson's disease

被引：42

作者：

Cecchini, Maria Paola ^{[1
]}

Osculati, Francesco ^{[2
]}

Ottaviani, Sarah ^{[3
]}

Boschi, Federico ^{[1
]}

Fasano, Alfonso ^{[4
]}

Tinazzi, Michele ^{[3
,5
]}

机构：

[1] Univ Verona, Dept Neurol & Movement Sci, Anat & Histol Sect, I-37134 Verona, Italy

[2] IRCCS Ctr Neurolesi Bonino Pulejo, Messina, Italy

[3] Osped Civile, Neurol Unit, I-37126 Verona, Italy

[4] Univ Toronto, Div Neurol, Movement Disorders Ctr, TWH,UHN, Toronto, ON, Canada

[5] Univ Verona, Dept Neurol & Movement Sci, Neurol Sect, I-37100 Verona, Italy

来源：

JOURNAL OF NEURAL TRANSMISSION | 2014年 / 121卷 / 02期

关键词：

Parkinson's disease; Taste; Whole Mouth Test (WMT); Taste Strip Test (TST); Smell; Sniffin' Sticks Test; SMELL;

D O I：

10.1007/s00702-013-1089-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

While olfactory deficit is already known to be associated with early-stage Parkinson's disease (PD), taste perception has not fully clarified so far. In this study, we investigated the taste performance in 61 patients with PD and 66 healthy controls (HC) using the Whole Mouth (WMT) and Taste Strip Tests (TST). In addition, we evaluated their olfactory function by means of the Sniffin' Sticks Test (SST). TST score was significantly lower in PD patients than in HC (TST score 11.0 +/- A 2.8 vs. 12.2 +/- A 2.1; p < 0.018) while WMT showed no difference. The olfactory evaluation confirmed the results reported in the literature with a significant reduction of the SST score in PD patients than in HC (SST score 7.0 +/- A 2.8 vs. 11.3 +/- A 2.8; p < 0.0001). The conflicting results revealed by TST and WMT could rely on a taste impairment not detectable at supra-threshold concentration of tastes, typical of the daily life. Possible biological correlates of taste impairment in PD are discussed.

引用

页码：119 / 122

页数：4

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