PD-L1 expression in liver metastasis: its clinical significance and discordance with primary tumor in colorectal cancer

被引:27
作者
Wei, Xiao-Li [1 ]
Luo, Xuan [2 ]
Sheng, Hui [3 ]
Wang, Yun [4 ]
Chen, Dong-Liang [1 ]
Li, Jia-Ning [5 ]
Wang, Feng-Hua [1 ]
Xu, Rui-Hua [1 ,6 ]
机构
[1] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr,Dept Med Oncol, 651 Dong Feng Rd East, Guangzhou 510060, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr,Dept Hepatobiliary Oncol, Guangzhou 510060, Peoples R China
[3] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Peoples R China
[4] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr,Dept Hematol Oncol, Guangzhou 510060, Peoples R China
[5] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr,Dept Clin Trial Ctr, Guangzhou 510060, Peoples R China
[6] Chinese Acad Med Sci, Res Unit Precis Diag & Treatment Gastrointestinal, Guangzhou 510060, Peoples R China
基金
中国国家自然科学基金;
关键词
PD-L1; Liver metastases; Primary tumor; Colorectal cancer; T-CELLS; HETEROGENEITY; PROGNOSIS; TARGET;
D O I
10.1186/s12967-020-02636-x
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
BackgroundThe outcomes of immune checkpoint inhibitors in cancer patients with liver metastases are poor, which may be related to a different tumor microenvironment in liver metastases from primary tumors. This study was aimed to analyze PD-L1 expression and the immune microenvironment status in liver metastases and compare the differences of PD-L1 expression between primary tumors and liver metastases of colorectal cancer.Methods74 cases of pathologically confirmed colorectal cancer with liver metastasis underwent resection from our hospital were included. Tissue microarrays were used for the interpretation of PD-L1 expression, cluster of differentiation 4 (CD4) and CD8 density by immunohistochemistry. We evaluated the disparity between primary tumor and liver metastasis in PD-L1 expression, CD4 and CD8 density and analyzed the factors associated with obvious PD-L1 disparity.ResultsThe expression of PD-L1 was positively related to the density of CD4 and CD8 in liver metastases. The expression of PD-L1 in liver metastases was higher than in primary tumors in certain subgroups, including patients with concurrent liver metastases (n=63, p=0.05), patients receiving concurrent resection of primary and metastatic tumors (n=56, p=0.04). The two subgroups generally reflected those without inconsistent external influences, such as treatment and temporal factors, between primary tumors and liver metastases. In these subgroups, the intrinsic differences of microenvironment between primary tumors and liver metastases could be identified. Furthermore, tumor differentiation [moderate vs. poor: OR=0.23, 95% CI: 0.03-0.99, p=0.05)] were demonstrated to be associated with obvious discordance of PD-L1 expression between primary tumors and liver metastases.ConclusionsThe expression of PD-L1 in liver metastases was higher than in primary tumors in subgroups, reflecting intrinsic microenvironment differences between primary and metastatic tumors. Obvious discordance of PD-L1 expression between primary tumor and liver metastasis was significantly related to the tumor differentiation.
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页数:10
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