Emerging Roles of RNA Modification: m6A and U-Tail

被引：275

作者：

Lee, Mihye ^{[1
,2
]}

Kim, Boseon ^{[1
,2
]}

Kim, V. Narry ^{[1
,2
]}

机构：

[1] Inst for Basic Sci Korea, IBS Ctr RNA Res, Seoul 151742, South Korea

[2] Seoul Natl Univ, Sch Biol Sci, Seoul 151742, South Korea

来源：

CELL | 2014年 / 158卷 / 05期

关键词：

ARABIDOPSIS MESSENGER-RNA; 3' END; MICRORNA BIOGENESIS; POLY(A) POLYMERASE; PRE-MICRORNA; NUCLEAR-RNA; 5' TERMINUS; STEM-LOOP; METHYLATION; URIDYLATION;

D O I：

10.1016/j.cell.2014.08.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although more than 100 types of RNA modification have been described thus far, most of them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent developments have unveiled that at least some of the modifications are considerably abundant and widely conserved. This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m(6)A) and uridylation (U-tail).

引用

页码：980 / 987

页数：8

共 50 条

[31] Advances in the role of m6A RNA modification in cancer metabolic reprogramming [J].

Han, Xiu ;

Wang, Lin ;

Han, Qingzhen .

CELL AND BIOSCIENCE, 2020, 10 (01)

[32] Epigenetic Mechanisms in Osteoporosis: Exploring the Power of m6A RNA Modification [J].

Tian, Shuo ;

Song, Yagang ;

Guo, Lin ;

Zhao, Hui ;

Bai, Ming ;

Miao, Mingsan .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2025, 29 (01)

[33] The emerging roles and mechanism of m6a in breast cancer progression [J].

Zhou, Mengying ;

Dong, Menglu ;

Yang, Xue ;

Gong, Jun ;

Liao, Xinghua ;

Zhang, Qi ;

Liu, Zeming .

FRONTIERS IN GENETICS, 2022, 13

[34] Emerging Roles and Mechanism of m6A Methylation in Cardiometabolic Diseases [J].

Xu, Zujie ;

Lv, Binbin ;

Qin, Ying ;

Zhang, Bing .

CELLS, 2022, 11 (07)

[35] The functional roles of m6A modification in T lymphocyte responses and autoimmune diseases [J].

Zhou, Huimin ;

Mao, Lingxiang ;

Xu, Huaxi ;

Wang, Shengjun ;

Tian, Jie .

CYTOKINE & GROWTH FACTOR REVIEWS, 2022, 65 :51-60

[36] The emerging roles of the interaction between m6A modification and c-Myc in driving tumorigenesis and development [J].

Zheng, Lemei ;

Li, Mengna ;

Wei, Jianxia ;

Chen, Shipeng ;

Xue, Changning ;

Zhan, Yuting ;

Duan, Yumei ;

Deng, Hongyu ;

Xiong, Wei ;

Li, Guiyuan ;

Zhou, Ming .

JOURNAL OF CELLULAR PHYSIOLOGY, 2022, 237 (07) :2758-2769

[37] The emerging importance role of m6A modification in liver disease [J].

Wang, Sheng ;

Gao, Songsen ;

Ye, Wufei ;

Li, Yueran ;

Luan, Jiajie ;

Lv, Xiongwen .

BIOMEDICINE & PHARMACOTHERAPY, 2023, 162

[38] Emerging role of m6A methylation modification in ovarian cancer [J].

Chang, Lin-Lin ;

Xu, Xia-Qing ;

Liu, Xue-Ling ;

Guo, Qian-Qian ;

Fan, Yan-Nan ;

He, Bao-Xia ;

Zhang, Wen-Zhou .

CANCER CELL INTERNATIONAL, 2021, 21 (01)

[39] Emerging role of m6A modification in osteogenesis of stem cells [J].

Zou, Zi ;

He, Tiantian ;

Liu, Ying ;

Zheng, Leliang ;

Zhong, Yancheng ;

Mo, Yuqing ;

Peng, Shuping ;

Shuai, Cijun .

JOURNAL OF BONE AND MINERAL METABOLISM, 2022, 40 (02) :177-188

[40] The Emerging Roles of RNA m6A Methylation and Demethylation as Critical Regulators of Tumorigenesis, Drug Sensitivity, and Resistance [J].

Lan, Qing ;

Liu, Pei Y. ;

Bell, Jessica L. ;

Wang, Jenny Y. ;

Huttelmaier, Stefan ;

Zhang, Xu Dong ;

Zhang, Lirong ;

Liu, Tao .

CANCER RESEARCH, 2021, 81 (13) :3431-3440

← 1 2 3 4 5 →