Emerging Roles of RNA Modification: m6A and U-Tail

被引：262

作者：

Lee, Mihye ^{[1
,2
]}

Kim, Boseon ^{[1
,2
]}

Kim, V. Narry ^{[1
,2
]}

机构：

[1] Inst for Basic Sci Korea, IBS Ctr RNA Res, Seoul 151742, South Korea

[2] Seoul Natl Univ, Sch Biol Sci, Seoul 151742, South Korea

来源：

CELL | 2014年 / 158卷 / 05期

关键词：

ARABIDOPSIS MESSENGER-RNA; 3' END; MICRORNA BIOGENESIS; POLY(A) POLYMERASE; PRE-MICRORNA; NUCLEAR-RNA; 5' TERMINUS; STEM-LOOP; METHYLATION; URIDYLATION;

D O I：

10.1016/j.cell.2014.08.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although more than 100 types of RNA modification have been described thus far, most of them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent developments have unveiled that at least some of the modifications are considerably abundant and widely conserved. This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m(6)A) and uridylation (U-tail).

引用

页码：980 / 987

页数：8