Ubiquitination: RING for destruction?

被引：442

作者：

Freemont, PS ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Mol Struct & Funct Lab, London WC2A 3PX, England

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0960-9822(00)00287-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein function. Recent results implicate the RING finger domain in specific ubiquitination events; it is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a variety of biological areas.

引用

页码：R84 / R87

页数：4

共 20 条

[1] A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae [J].

Bordallo, J ;

Wolf, DH .

FEBS LETTERS, 1999, 448 (2-3) :244-248

[2]

Duprez E, 1999, J CELL SCI, V112, P381

[3] Components of an SCE ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle [J].

Freed, E ;

Lacey, KR ;

Huie, P ;

Lyapina, SA ;

Deshaies, RJ ;

Stearns, T ;

Jackson, PK .

GENES & DEVELOPMENT, 1999, 13 (17) :2242-2257

[4] Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 [J].

Honda, R ;

Yasuda, H .

EMBO JOURNAL, 1999, 18 (01) :22-27

[5]

Hu G, 1999, MOL CELL BIOL, V19, P724

[6] BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression [J].

Jensen, DE ;

Proctor, M ;

Marquis, ST ;

Gardner, HP ;

Ha, SI ;

Chodosh, LA ;

Ishov, AM ;

Tommerup, N ;

Vissing, H ;

Sekido, Y ;

Minna, J ;

Borodovsky, A ;

Schultz, DC ;

Wilkinson, KD ;

Maul, GG ;

Barlev, N ;

Berger, SL ;

Prendergast, GC ;

Rauscher, FJ .

ONCOGENE, 1998, 16 (09) :1097-1112

[7] The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase [J].

Joazeiro, CAP ;

Wing, SS ;

Huang, HK ;

Leverson, JD ;

Hunter, T ;

Liu, YC .

SCIENCE, 1999, 286 (5438) :309-312

[8] Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase [J].

Kamura, T ;

Koepp, DM ;

Conrad, MN ;

Skowyra, D ;

Moreland, RJ ;

Iliopoulos, O ;

Lane, WS ;

Kaelin, WG ;

Elledge, SJ ;

Conaway, RC ;

Harper, JW ;

Conway, JW .

SCIENCE, 1999, 284 (5414) :657-661

[9] Herpes simplex virus type 1 immediate-early protein Vmw110 inhibits progression of cells through mitosis and from G1 into S phase of the cell cycle [J].

Lomonte, P ;

Everett, RD .

JOURNAL OF VIROLOGY, 1999, 73 (11) :9456-9467

[10] RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination [J].

Lorick, KL ;

Jensen, JP ;

Fang, SY ;

Ong, AM ;

Hatakeyama, S ;

Weissman, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11364-11369

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