3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives

被引：14

作者：

Kaneko, Hideki ^{[1
]}

Ikawa, Takashi ^{[1
]}

Yamamoto, Yuta ^{[2
]}

Arulmozhiraja, Sundaram ^{[2
]}

Tokiwa, Hiroaki ^{[2
]}

Akai, Shuji ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, 1-6 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Rikkyo Univ, Dept Chem, Res Ctr Smart Mol, Toshima Ku, 3-34-1 Nishi Ikebukuro, Tokyo 1718501, Japan

来源：

SYNLETT | 2018年 / 29卷 / 07期

关键词：

benzodiazepines; benzynes; triflyloxy group; imidazolidinones; regioselectivity; directing group; REGIOSELECTIVE DIELS-ALDER; SELECTIVE SYNTHESIS; ARYNE; GENERATION; CONSTRUCTION; BENZODIAZEPINE; CHEMISTRY; BORYL;

D O I：

10.1055/s-0036-1591924

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile synthesis of 1,4-benzodiazepine derivatives through the reaction of various 3-(trifluoromethanesulfonyloxy)benzynes with N-(p-toluenesulfonyl) imidazolidin-2-ones is reported. This reaction system provides a 1,4-benzodiazepine bearing a trifluoromethanesulfonyloxy group as a single regioisomer among the four possible regioisomers.

引用

页码：943 / +

页数：7

共 34 条

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