Predicted Cellular Immunity Population Coverage Gaps for SARS-CoV-2 Subunit Vaccines and Their Augmentation by Compact Peptide Sets

被引：28

作者：

Liu, Ge ^{[1
,2
]}

Carter, Brandon ^{[1
,2
]}

Gifford, David K. ^{[1
,2
,3
]}

机构：

[1] MIT, Comp Sci & Artificial Intelligence Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[2] MIT, Elect Engn & Comp Sci, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] MIT, Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA

来源：

CELL SYSTEMS | 2021年 / 12卷 / 01期

关键词：

MHC CLASS-I; COVID-19;

D O I：

10.1016/j.cels.2020.11.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Subunit vaccines induce immunity to a pathogen by presenting a component of the pathogen and thus inherently limit the representation of pathogen peptides for cellular immunity-based memory. We find that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subunit peptides may not be robustly displayed by the major histocompatibility complex (MHC) molecules in certain individuals. We introduce an augmentation strategy for subunit vaccines that adds a small number of SARS-CoV-2 peptides to a vaccine to improve the population coverage of pathogen peptide display. Our population coverage estimates integrate clinical data on peptide immunogenicity in convalescent COVID-19 patients and machine learning predictions. We evaluate the population coverage of 9 different subunits of SARS-CoV-2, including 5 functional domains and 4 full proteins, and augment each of them to fill a predicted coverage gap.

引用

页码：102 / +

页数：10

共 32 条

[1]

[Anonymous], 2020, Nucleic Acids Res, V48, pW449, DOI DOI 10.1093/NAR/GKAA379

[2] Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner [J].