Pueraria tuberosa: A Review on Traditional Uses, Pharmacology, and Phytochemistry

被引:48
作者
Bharti, Ram [1 ,2 ]
Chopra, Bhupinder Singh [1 ,2 ]
Raut, Sachin [1 ,2 ]
Khatri, Neeraj [1 ,2 ]
机构
[1] CSIR, IMTECH Ctr Anim Resources & Experimentat iCARE, Inst Microbial Technol CSIR IMTECH, Chandigarh, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad, India
关键词
in vivo studies; pharmacological properties; phytochemical constituents; traditional uses; Pueraria tuberosa; P-COUMARIC ACID; NF-KAPPA-B; CISPLATIN-INDUCED NEPHROTOXICITY; COMMON DIETARY POLYPHENOL; BETA-SITOSTEROL; DIABETIC-NEPHROPATHY; ANTIOXIDANT ACTIVITY; INSULIN SENSITIVITY; SIGNALING PATHWAY; BLOOD-PRESSURE;
D O I
10.3389/fphar.2020.582506
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Pueraria tuberosa (Roxb. ex Willd.) DC. (Fabaceae), also known as Indian Kudzu (vidari kand), is a perennial herb distributed throughout India and other Asian countries. Traditionally, tuber and leaves of this plant have extensively been reported for nutritional and medicinal properties in Ayurveda as well as in Chinese traditional practices. The objective of the present review is to compile and update the published data on traditional uses, pharmacological potential, and phytochemistry of compounds isolated from the plant Pueraria tuberosa. P. tuberosa extracts and its purified compounds possess multiple activities such as anticancer, anticonvulsant, antidiabetic, antifertility, anti-inflammatory, antioxidant, anti-stress, antiulcerogenic, cardioprotective, hypolipidemic, hepatoprotective, immunomodulatory, nephroprotective, nootropic, neuroprotective, and wound healing. Tuber and leaf extracts of P. tuberosa contain several bioactive constituents such as puerarin, daidzein, genistein, quercetin, irisolidone, biochanin A, biochanin B, isoorientin, and mangiferin, which possess an extensive range of pharmacological activities. The extensive range of pharmacological properties of P. tuberosa provides opportunities for further investigation and presents a new approach for the treatment of ailments. Many phytochemicals have been identified and characterized from P. tuberosa; however, some of them are still unexplored, and there is no supporting data for their activities and exact mechanisms of action. Therefore, further investigations are warranted to unravel the mechanisms of action of individual constituents of this plant.
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页数:20
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