Pharmacological inhibition of the alternative pathway by anti-factor B leads to neuroprotection and reduced apoptosis after experimental closed head injury in mice

被引：0
|
作者：
Leinhase, I.
Thurman, J. M.
Harhausen, D.
Smith, W. R.
Schmidt, O. I.
Ertel, W.
Holers, V. M.
Stahel, P. F.
机构：
[1] Charite Univ Med Berlin, Sch Med, Dept Trauma & Reconstruct Surg, Berlin, Germany
[2] Univ Colorado, Hlth Sci Ctr, Dept Med, Div Rheumatol, Denver, CO 80262 USA
[3] Univ Colorado, Sch Med, Dept Orthopaed Surg, Denver Hlth Med Ctr, Denver, CO 80262 USA
来源：
MOLECULAR IMMUNOLOGY | 2007年 / 44卷 / 1-3期
关键词：
D O I：
10.1016/j.molimm.2006.07.133
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
128
引用
收藏
页码：203 / 204
页数：2
相关论文
共 13 条
  • [1] Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice
    Iris Leinhase
    Michal Rozanski
    Denise Harhausen
    Joshua M Thurman
    Oliver I Schmidt
    Amir M Hossini
    Mohy E Taha
    Daniel Rittirsch
    Peter A Ward
    V Michael Holers
    Wolfgang Ertel
    Philip F Stahel
    Journal of Neuroinflammation, 4
  • [2] Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice
    Leinhase, Iris
    Rozanski, Michal
    Harhausen, Denise
    Thurman, Joshua M.
    Schmidt, Oliver I.
    Hossini, Amir M.
    Taha, Mohy E.
    Rittirsch, Daniel
    Ward, Peter A.
    Holers, V. Michael
    Ertel, Wolfgang
    Stahel, Philip F.
    JOURNAL OF NEUROINFLAMMATION, 2007, 4 (1)
  • [3] Central nervous system-targeted complement inhibition mediates neuroprotection after closed head injury in transgenic mice
    Rancan, M
    Morganti-Kossmann, MC
    Barnum, TR
    Saft, T
    Schmidt, TOI
    Ertel, WG
    Stahel, PF
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (09): : 1070 - 1074
  • [4] Absence of CD59a leads to exacerbated neuroinflammation and neuropathology after experimental closed head injury in mice
    Stahel, Philip F.
    Leinhase, Iris
    Persigehl, Ivonne
    Stoll, Christiane
    Ertel, Wolfgang
    Morgan, B. Paul
    MOLECULAR IMMUNOLOGY, 2007, 44 (16) : 3943 - 3943
  • [5] Elevated intracranial interleukin-18 levels after closed head injury in humans and mice: Evidence of neuroprotection by interleukin-18-binding-protein after experimental head injury
    Yatsiv, I
    Stahel, PF
    Novick, D
    Rubinstein, M
    Dinarello, CA
    Marganti-Kossmann, MC
    Morganti-Kossmann, T
    Shohami, E
    INTENSIVE CARE MEDICINE, 2001, 27 : S287 - S287
  • [6] MICE WITH GENETIC DEFICIENCY FOR COMPLEMENT RECEPTOR TYPE 2 (CR2) SHOW NEUROPROTECTION AFTER EXPERIMENTAL CLOSED HEAD INJURY
    Keene, Chesleigh
    Neher, Miriam
    Rich, Megan
    Weckbach, Sebastian
    Bolden, Ashley
    Losacco, Justin
    Holers, V. Michael
    Stahel, Philip F.
    JOURNAL OF NEUROTRAUMA, 2013, 30 (15) : A150 - A150
  • [7] Mice with genetic deficiency for complement receptor type 2 (CR2) show neuroprotection after experimental closed head injury
    Neher, Miriam
    Rich, Megan
    Keene, Chesleigh
    Weckbach, Sebastian
    Bolden, Ashley
    Losacco, Justin
    Holers, Michael
    Stahel, Philip
    BRAIN INJURY, 2014, 28 (5-6) : 564 - 564
  • [8] Heat acclimation increases hypoxia-inducible factor 1α and erythropoietin receptor expression:: implication for neuroprotection after closed head injury in mice
    Shein, NA
    Horowitz, M
    Alexandrovich, AG
    Tsenter, J
    Shohami, E
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2005, 25 (11): : 1456 - 1465
  • [9] Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation
    Iris Leinhase
    V Michael Holers
    Joshua M Thurman
    Denise Harhausen
    Oliver I Schmidt
    Malte Pietzcker
    Mohy E Taha
    Daniel Rittirsch
    Markus Huber-Lang
    Wade R Smith
    Peter A Ward
    Philip F Stahel
    BMC Neuroscience, 7
  • [10] Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation
    Leinhase, Iris
    Holers, V. Michael
    Thurman, Joshua M.
    Harhausen, Denise
    Schmidt, Oliver I.
    Pietzcker, Malte
    Taha, Mohy E.
    Rittirsch, Daniel
    Huber-Lang, Markus
    Smith, Wade R.
    Ward, Peter A.
    Stahel, Philip F.
    BMC NEUROSCIENCE, 2006, 7 (1)
12