Immunomodulatory effect of ghrelin in the intestinal mucosa

被引：29
作者：
Eissa, N. [1 ]
Ghia, J. E. [1 ,2 ]
机构：
[1] Univ Manitoba, Immunol, Winnipeg, MB R3E OT5, Canada
[2] Univ Manitoba, Childrens Hosp Res Inst Manitoba, IBD Clin & Res Ctr, Internal Med Sect Gastroenterol, Winnipeg, MB R3E OT5, Canada
来源：
NEUROGASTROENTEROLOGY AND MOTILITY | 2015年 / 27卷 / 11期
基金：
加拿大健康研究院;
关键词：
apoptosis; colitis; ghrelin; immune regulation; macrophages; T helper cells; VAGUS NERVE-STIMULATION; PROINFLAMMATORY CYTOKINES; INDUCED GASTROPROTECTION; SECRETAGOGUE RECEPTOR; DISEASE-ACTIVITY; INDUCED COLITIS; PLASMA GHRELIN; CROHNS-DISEASE; ACTIVATION; CELLS;
D O I：
10.1111/nmo.12703
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The gastrointestinal tract is the largest endocrine organ in the body and it produces a wide array of hormones and neuropeptides. Ghrelin, a 28-amino acid hormone produced mainly by the X/A-like endocrine cells in the gastric mucosa, has widespread tissue distribution and diverse physiological functions such as hormonal, orexigenic, metabolic, cardiovascular, neurological and immunological activities. Recent research has implicated ghrelin in gastrointestinal pathological conditions and immune system regulation, but its contribution is controversial. Although ghrelin levels are elevated in clinical active inflammatory bowel diseases, confirmation of its exact role using experimental models remains unclear. This review discusses the conflicting effects of ghrelin on intestinal inflammation, through the different possible immune and intracellular mechanisms and highlights new findings.
引用
收藏
页码：1519 / 1527
页数：9
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