Unexpected Role of Anionic Ligands in the Ruthenium-Catalyzed Base-Free Selective Hydrogenation of Aldehydes

被引：26

作者：

Dupau, Philippe ^{[1
]}

Bonomo, Lucia ^{[1
]}

Kermorvan, Laurent ^{[1
]}

机构：

[1] Firmenich Co, Corp R&D Div, CH-1283 La Plaine, GE, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 43期

关键词：

aldehydes; base-free conditions; homogeneous catalysis; hydrogenation; ruthenium; ASYMMETRIC HYDROGENATION; DIHYDRIDE COMPLEXES; KETONES; ETA-2-DIHYDROGEN; MECHANISM; ESTERS;

D O I：

10.1002/anie.201304912

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bigger and better: The replacement of anionic chloride ligands in Noyori-type [(diamine)(diphosphine)RuCl2] catalysts with bulky carboxylate ligands enabled the efficient selective hydrogenation of a variety of aldehydes under base-free conditions (see scheme). Turnover numbers of up to 100 000 were reached in the presence of a bulky carboxylic acid co-catalyst. This type of catalytic system probably operates through an inner-sphere mechanism. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11347 / 11350

页数：4

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