Role of Toll-like receptor 4 in the initiation and progression of atherosclerotic disease

被引：150
|
作者：
Pasterkamp, G
van Keulen, JK
de Kleijn, DPV
机构：
[1] Univ Med Ctr G02 523, Expt Cardiol Lab, NL-3584 CX Utrecht, Netherlands
[2] Interuniv Cardiol Inst Netherlands, Dept Cardiol, Utrecht, Netherlands
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 34卷 / 05期
关键词：
arteriosclerosis; atherosclerosis; inflammation; innate immunity; plaque vulnerability; Toll-like receptor 4;
D O I：
10.1111/j.1365-2362.2004.01338.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The family of Toll-like receptors (TLRs) initiates an innate immune response after recognition of pathogen-associated molecular patterns (PAMPs). Evidence is accumulating that TLRs, and particularly TLR4, are important players in the initiation and progression of atherosclerotic disease. Not only exogenous ligands but also endogenous ligands that are expressed during arterial injury are recognized by TLR4. Mouse knockout studies and epidemiological studies of human TLR4 polymorphisms have demonstrated that the TLR4 might play a role in the initiation and progression of atherosclerosis. This review will summarize the latest progression in research on the role of TLR4 in arterial occlusive disease In addition, the potential of intervention in TLR4 signalling to influence progression of atherosclerotic disease is discussed.
引用
收藏
页码：328 / 334
页数：7
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