Diabetes and Cancer

被引：42
作者：
Zelenko, Zara [1 ]
Gallagher, Emily Jane [1 ]
机构：
[1] Icahn Sch Med Mt Sinai, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2014年 / 43卷 / 01期
关键词：
Diabetes mellitus; Obesity; Metabolic syndrome; Cancer; Hyperinsulinemia; Hyperglycemia; Inflammation; GROWTH-FACTOR-I; EPITHELIAL-MESENCHYMAL TRANSITION; INSULIN-RECEPTOR ISOFORM; SQUAMOUS-CELL CARCINOMA; POPULATION-BASED COHORT; NECROSIS-FACTOR-ALPHA; STAGE BREAST-CANCER; METABOLIC SYNDROME; PROSTATE-CANCER; MAMMARY TUMORIGENESIS;
D O I：
10.1016/j.ecl.2013.09.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes is a worldwide health problem that has been increasingly associated with various types of cancers. Epidemiologic studies have shown an increased risk of cancer as well as a higher mortality rate in patients with type 2 diabetes (T2D). The biologic mechanisms driving the link between T2D and cancer are not well understood. In this review, various proposed mechanisms are addressed to explain the relationship between T2D and cancer. Understanding the precise mechanisms that link T2D, obesity, and the metabolic syndrome with cancer will aid in developing treatments that will reduce mortality in individuals with T2D and cancer.
引用
收藏
页码：167 / +
页数：20
相关论文
共 113 条
[1]   CANCER RISK IN PATIENTS WITH DIABETES-MELLITUS [J].
ADAMI, HO ;
MCLAUGHLIN, J ;
EKBOM, A ;
BERNE, C ;
SILVERMAN, D ;
HACKER, D ;
PERSSON, I .
CANCER CAUSES & CONTROL, 1991, 2 (05) :307-314
[2]   Inflammation and cancer: How hot is the link? [J].
Aggarwal, Bharat B. ;
Shishodia, Shishir ;
Sandur, Santosh K. ;
Pandey, Manoj K. ;
Sethi, Gautam .
BIOCHEMICAL PHARMACOLOGY, 2006, 72 (11) :1605-1621
[3]  
Al Moustafa Ala-Eddin, 2012, Front Biosci (Schol Ed), V4, P671
[4]   Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis [J].
Ancrile, Brooke ;
Lim, Kian-Huat ;
Counter, Christopher M. .
GENES & DEVELOPMENT, 2007, 21 (14) :1714-1719
[5]   Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C [J].
Arase, Yasuji ;
Kobayashi, Mariko ;
Suzuki, Fumitaka ;
Suzuki, Yoshiyuki ;
Kawamura, Yusuke ;
Akuta, Norio ;
Kobayashi, Masahiro ;
Sezaki, Hitomi ;
Saito, Satoshi ;
Hosaka, Tetsuya ;
Ikeda, Kenji ;
Kumada, Hiromitsu ;
Kobayashi, Tetsuro .
HEPATOLOGY, 2013, 57 (03) :964-973
[6]   Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten [J].
Barbieri, Isaia ;
Pensa, Sara ;
Pannellini, Tania ;
Quaglino, Elena ;
Maritano, Diego ;
Demaria, Marco ;
Voster, Alessandra ;
Turkson, James ;
Cavallo, Federica ;
Watson, Christine J. ;
Provero, Paolo ;
Musiani, Piero ;
Poli, Valeria .
CANCER RESEARCH, 2010, 70 (06) :2558-2567
[7]  
Becker Susen, 2009, Archives of Physiology and Biochemistry, V115, P86, DOI 10.1080/13813450902878054
[8]   Novel Tissue-Specific Mechanism of Regulation of Angiogenesis and Cancer Growth in Response to Hyperglycemia [J].
Bhattacharyya, Sanghamitra ;
Sul, Kristina ;
Krukovets, Irene ;
Nestor, Carla ;
Li, Jianbo ;
Adognravi, Olga Stenina .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2012, 1 (06) :e005967
[9]   Metabolic Syndrome and Breast Cancer in the Me-Can (Metabolic Syndrome and Cancer) Project [J].
Bjorge, Tone ;
Lukanova, Annekatrin ;
Jonsson, Hakan ;
Tretli, Steinar ;
Ulmer, Hanno ;
Manjer, Jonas ;
Stocks, Tanja ;
Selmer, Randi ;
Nagel, Gabriele ;
Almquist, Martin ;
Concin, Hans ;
Hallmans, Goran ;
Haggstrom, Christel ;
Stattin, Par ;
Engeland, Anders .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2010, 19 (07) :1737-1745
[10]   Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults [J].
Borena, Wegene ;
Strohmaier, Susanne ;
Lukanova, Annekatrin ;
Bjorge, Tone ;
Lindkvist, Bjorn ;
Hallmans, Goran ;
Edlinger, Michael ;
Stocks, Tanja ;
Nagel, Gabriele ;
Manjer, Jonas ;
Engeland, Anders ;
Selmer, Randi ;
Haggstrom, Christel ;
Tretli, Steinar ;
Concin, Hans ;
Jonsson, Hakan ;
Stattin, Par ;
Ulmer, Hanno .
INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (01) :193-200
12345678910