B cells in the formation of tertiary lymphoid organs in autoimmunity, transplantation and tumorigenesis

被引：35

作者：

Corsiero, Elisa ^{[1
]}

Delvecchio, Francesca Romana ^{[1
]}

Bombardieri, Michele ^{[1
]}

Pitzalis, Costantino ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Ctr Expt Med & Rheumatol, London, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2019年 / 57卷

基金：

英国医学研究理事会;

关键词：

PLASMA-CELLS; GERMINAL-CENTERS; EXPRESSION; NEOGENESIS; INFILTRATION; ACTIVATION; INFECTION; PATHWAY; DISEASE; CANCER;

D O I：

10.1016/j.coi.2019.01.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tertiary lymphoid organs named also tertiary lymphoid structures (TLS) often occur at sites of autoimmune inflammation, organ transplantation and cancer. Although the mechanisms for their formation/function are not entirely understood, it is known that TLS can display features of active germinal centres supporting the proliferation and differentiation of (auto)-reactive B cells. In this Review, we discuss current knowledge on TLS-associated B cells with particular reference on how within diseased tissues these structures are linked to either deleterious or protective outcomes in patients and the potential for therapeutic targeting of TLS through novel drugs.

引用

收藏

页码：46 / 52

页数：7

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