CNS Anticancer Drug Discovery and Development Conference White Paper

被引：35

作者：

Levin, Victor A. ^{[1
,2
,3
]}

Tonge, Peter J. ^{[4
]}

Gallo, James M. ^{[5
]}

Birtwistle, Marc R. ^{[5
]}

Dar, Arvin C. ^{[5
]}

Iavarone, Antonio ^{[6
]}

Paddison, Patrick J. ^{[7
]}

Heffron, Timothy P. ^{[8
]}

Elmquist, William F. ^{[9
]}

Lachowicz, Jean E. ^{[10
]}

Johnson, Ted W. ^{[11
]}

White, Forest M. ^{[12
]}

Sul, Joohee ^{[13
]}

Smith, Quentin R. ^{[14
]}

Shen, Wang ^{[15
]}

Sarkaria, Jann N. ^{[16
]}

Samala, Ramakrishna ^{[14
]}

Wen, Patrick Y. ^{[17
]}

Berry, Donald A. ^{[2
]}

Petter, Russell C. ^{[18
]}

机构：

[1] Kaiser Permanente, Redwood City, CA USA

[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[3] Univ Calif San Francisco, San Francisco, CA 94143 USA

[4] SUNY Stony Brook, Stony Brook, NY 11794 USA

[5] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[6] Columbia Univ, Inst Canc Genet, New York, NY USA

[7] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[8] Genentech Inc, San Francisco, CA 94080 USA

[9] Univ Minnesota, Sch Pharm, Minneapolis, MN USA

[10] Angiochem Inc, Montreal, PQ, Canada

[11] Pfizer Oncol, San Diego, CA USA

[12] MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[13] US FDA, Silver Spring, MD USA

[14] Texas Tech Univ, Sch Pharm, Amarillo, TX USA

[15] NewGen Therapeut Inc, Menlo Pk, CA USA

[16] Mayo Clin, Rochester, MN USA

[17] Dana Farber Canc Inst, Boston, MA 02115 USA

[18] Celgene Avil Res, Bedford, MA USA

来源：

NEURO-ONCOLOGY | 2015年 / 17卷

关键词：

brain metastasis; chemotherapy; glioma; medulloblastoma; pharmacokinetics; pharmacology; PHASE-II TRIAL; RECURRENT GLIOBLASTOMA-MULTIFORME; BRAIN-TUMOR CONSORTIUM; CENTRAL-NERVOUS-SYSTEM; HIGH-DOSE METHOTREXATE; CANCER-TREATMENT GROUP; HIGH-GRADE GLIOMAS; FRACTIONATION RADIATION-THERAPY; RADIOTHERAPY PLUS PROCARBAZINE; PROGRESSION-FREE SURVIVAL;

D O I：

10.1093/neuonc/nov169

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Following the first CNS Anticancer Drug Discovery and Development Conference, the speakers from the first 4 sessions and organizers of the conference created this White Paper hoping to stimulate more and better CNS anticancer drug discovery and development. The first part of the White Paper reviews, comments, and, in some cases, expands on the 4 session areas critical to new drug development: pharmacological challenges, recent drug approaches, drug targets and discovery, and clinical paths. Following this concise review of the science and clinical aspects of new CNS anticancer drug discovery and development, we discuss, under the rubric "Accelerating Drug Discovery and Development for Brain Tumors," further reasons why the pharmaceutical industry and academia have failed to develop new anticancer drugs for CNS malignancies and what it will take to change the current status quo and develop the drugs so desperately needed by our patients with malignant CNS tumors. While this White Paper is not a formal roadmap to that end, it should be an educational guide to clinicians and scientists to help move a stagnant field forward.

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页码：1 / 26

页数：26

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