Chlorophyll-Catalyzed Visible-Light-Mediated Synthesis of Tetrahydroquinolines from N,N-Dimethylanilines and Maleimides

被引：96

作者：

Guo, Jun-Tao

Yang, Da-Cheng

Guan, Zhi

He, Yan-Hong

机构：

[1] Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 04期

基金：

中国国家自然科学基金;

关键词：

TERTIARY ANILINES; N-METHYLANILINES; CYCLIZATION;

D O I：

10.1021/acs.joc.6b03034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Natural pigment chlorophyll was used as a green photosensitizer for the first time in a visible-light photoredox catalysis for the efficient synthesis of tetrahydroquinolines from N,N-dimethylanilines and maleimides in an air atmosphere. The reaction involves direct cyclization via an sp(3) C-H bond functionalization process to afford products in moderate to high yields (61-98%) from a wide range of substrates with a low loading of chlorophyll under mild conditions. This work demonstrates the potential benefits of chlorophyll as photo-sensitizer in visible light catalysis.

引用

页码：1888 / 1894

页数：7

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