Total Synthesis of (3S, 5R, 3′S, 5′R)-Capsorubin

被引：3

作者：

Frederico, Daniel ^{[1
]}

Constantino, Mauricio G. ^{[1
]}

Donate, Paulo M. ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2009年 / 20卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

carotenoid; capsorubin; crocetindial; cyclopentane keto-alkohol; synthesis; CAPSICUM-ANNUUM L; CAROTENOIDS; CAPSORUBIN; CAPSANTHIN; CANCER; REARRANGEMENT; LYCOPENE; ESTERS;

D O I：

10.1590/S0103-50532009000500013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The total synthesis of enantiomerically enriched (3S, 5R, 3' S, 5'R)-capsorubin (1) by aldol condensation of (1R, 4S)-1-(4-hydroxy-1,2,2-trimethyl-cyclopentyl)ethanone (2a) and crocetindial (3) is described. An alternative, short eight-step synthesis of the optically active compound 2a (ee 89%) is also reported.

引用

页码：888 / U148

页数：15

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