Total Synthesis of (3S, 5R, 3′S, 5′R)-Capsorubin

被引：3
|
作者：
Frederico, Daniel [1 ]
Constantino, Mauricio G. [1 ]
Donate, Paulo M. [1 ]
机构：
[1] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2009年 / 20卷 / 05期
基金：
巴西圣保罗研究基金会;
关键词：
carotenoid; capsorubin; crocetindial; cyclopentane keto-alkohol; synthesis; CAPSICUM-ANNUUM L; CAROTENOIDS; CAPSORUBIN; CAPSANTHIN; CANCER; REARRANGEMENT; LYCOPENE; ESTERS;
D O I：
10.1590/S0103-50532009000500013
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The total synthesis of enantiomerically enriched (3S, 5R, 3' S, 5'R)-capsorubin (1) by aldol condensation of (1R, 4S)-1-(4-hydroxy-1,2,2-trimethyl-cyclopentyl)ethanone (2a) and crocetindial (3) is described. An alternative, short eight-step synthesis of the optically active compound 2a (ee 89%) is also reported.
引用
收藏
页码：888 / U148
页数：15
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