Enhanced Antimicrobial Activity of Amine-Phosphonium (N-P) Hybrid Polymers Against Gram-Negative and Gram-Positive Bacteria

被引：17

作者：

Bansal, Ruby ^{[1
,2
]}

Pathak, Rajiv ^{[3
]}

Jha, Diksha ^{[3
]}

Kumar, Pradeep ^{[1
]}

Gautam, Hemant K. ^{[3
]}

机构：

[1] Delhi Univ Campus, CSIR Inst Genom & Integrat Biol, Nucle Acids Res Lab, Delhi, India

[2] Acad Sci & Innovat Res, New Delhi, India

[3] CSIR Inst Genom & Integrat Biol South Campus, Microbial Biotechnol Lab, New Delhi 10007, India

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2015年 / 64卷 / 02期

关键词：

linear polyethylenimine; Antimicrobial activity; phosphonium salts; cationic polymers; ANTIBACTERIAL ACTIVITY; POLYETHYLENIMINE; COPOLYMERS; SALTS; NANOPARTICLES; DERIVATIVES; PROPERTY; BIOCIDES; BEHAVIOR;

D O I：

10.1080/00914037.2014.886246

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The authors report synthesis, characterization and evaluation of a series of linear polyethylenimine (lPEI)-grafted butyltriphenylphosphonium bromide (LBTP) polymers (N-P hybrid polymers) for their antimicrobial activity on various Gram-positive and Gram-negative bacteria. Polymers with similar to 5.8-13.8% substitution of butyltriphenylphosphonium bromide (BTP) on the backbone of lPEI showed enhanced charge density as compared to native lPEI confirming the conjugation of BTP onto lPEI. These modified polymers displayed low hemolytic activity and excellent antimicrobial activity against these two types of bacteria with one of the modified polymers, LBTP-40, was found to exhibit high antimicrobial activity in all the strains. [GRAPHICS]

引用

页码：84 / 89

页数：6

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