Genome-wide meta-analysis of cognitive empathy: heritability, and correlates with sex, neuropsychiatric conditions and cognition

被引：94

作者：

Warrier, V. ^{[1
]}

Grasby, K. L. ^{[2
]}

Uzefovsky, F. ^{[1
,3
]}

Toro, R. ^{[4
,5
,6
]}

Smith, P. ^{[1
]}

Chakrabarti, B. ^{[7
]}

Khadake, J. ^{[8
,9
]}

Mawbey-Adamson, E. ^{[8
,9
]}

Litterman, N. ^{[10
]}

Hottenga, J-J ^{[11
,12
,13
]}

Lubke, G. ^{[14
]}

Boomsma, D. I. ^{[11
]}

Martin, N. G. ^{[2
]}

Hatemi, P. K. ^{[15
]}

Medland, S. E. ^{[2
]}

Hinds, D. A. ^{[10
]}

Bourgeron, T. ^{[4
,5
,6
]}

Baron-Cohen, S. ^{[1
,16
]}

机构：

[1] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, Cambs, England

[2] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia

[3] Ben Gurion Univ Negev, Dept Psychol, Beer Sheva, Israel

[4] Inst Pasteur, CNRS, UMR Genes Synapses & Cognit 3571, Paris, France

[5] Univ Paris Diderot, Sorbonne Paris Cite, Human Genet & Cognit Funct, Paris, France

[6] Inst Pasteur, Paris, France

[7] Univ Reading, Ctr Integrat Neurosci & Neurodynam, Sch Psychol & Clin Language Sci, Reading, Berks, England

[8] Univ Cambridge, NIHR Cambridge BioResource, Cambridge, England

[9] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England

[10] 23andMe Inc, Mountain View, CA USA

[11] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

[12] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands

[13] Vrije Univ Amsterdam, Neurosci Campus Amsterdam, Amsterdam, Netherlands

[14] Univ Notre Dame, Dept Psychol, South Bend, IN USA

[15] Penn State Univ, Polit Sci Microbiol & Biochem, University Pk, PA 16802 USA

[16] Cambridgeshire & Peterborough NHS Fdn Trust CPFT, CLASS Clin, Cambridge, Cambs, England

来源：

MOLECULAR PSYCHIATRY | 2018年 / 23卷 / 06期

基金：

美国国家科学基金会; 英国惠康基金; 美国国家卫生研究院; 英国医学研究理事会; 以色列科学基金会;

关键词：

MIND; ASSOCIATION; EYES; INTELLIGENCE; PERSONALITY; PERFORMANCE; DISORDERS; CHILDREN; EMOTION; IQ;

D O I：

10.1038/mp.2017.122

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We conducted a genome-wide meta-analysis of cognitive empathy using the 'Reading the Mind in the Eyes' Test (Eyes Test) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe Inc., and an additional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane Longitudinal Twin Study. We confirmed a female advantage on the Eyes Test (Cohen's d = 0.21, P < 2.2 x 10(-16)), and identified a locus in 3p26.1 that is associated with scores on the Eyes Test in females (rs7641347, P-meta = 1.58 x 10(-8)). Common single nucleotide polymorphisms explained 5.8% (95% CI: 4.5%-7.2%; P = 1.00 x 10(-17)) of the total trait variance in both sexes, and we identified a twin heritability of 28% (95% CI: 13%-42%). Finally, we identified significant genetic correlation between the Eyes Test and anorexia nervosa, openness (NEO-Five Factor Inventory), and different measures of educational attainment and cognitive aptitude.

引用

页码：1402 / 1409

页数：8

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