Recent advances in personalized colorectal cancer research

被引：51

作者：

Kraus, Sarah

Nabiochtchikov, Ilana

Shapira, Shiran

Arber, Nadir ^{[1
]}

机构：

[1] Tel Aviv Sourasky Med Ctr, Integrated Canc Prevent Ctr, IL-64239 Tel Aviv, Israel

来源：

CANCER LETTERS | 2014年 / 347卷 / 01期

关键词：

Colorectal cancer (CRC); Biomarkers; KRAS; Monoclonal antibodies (mAbs); Oncotype; Epigenetic markers; K-RAS MUTATIONS; CARCINOEMBRYONIC ANTIGEN; PIK3CA MUTATION; COLON-CANCER; TARGETED THERAPIES; DNA METHYLATION; GENE-EXPRESSION; TUMOR-MARKERS; ASPIRIN USE; RISK;

D O I：

10.1016/j.canlet.2014.01.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer is one of the most prevalent cancers and a leading cause of cancer-related death. It is also curable if detected early. The prognosis for metastatic colorectal cancer remains poor and resistance to chemotherapy is still a major obstacle in effective treatment. While many patients do not clinically benefit from chemotherapy, others experience adverse reactions resulting in dose modifications or treatment withdrawal, thereby reducing treatment efficacy. Research efforts attempt to identify reliable biomarkers which will guide clinicians in decision making, while matching suitable therapeutic regimens. We here review currently known molecular biomarkers used for the personalized treatment of colorectal cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：15 / 21

页数：7

共 66 条

[1] The AKT/IκB kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-κB and β-catenin [J].

Agarwal, A ;

Das, K ;

Lerner, N ;

Sathe, S ;

Cicek, M ;

Casey, G ;

Sizemore, N .

ONCOGENE, 2005, 24 (06) :1021-1031

[2] ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis [J].

Agesen, Trude H. ;

Sveen, Anita ;

Merok, Marianne A. ;

Lind, Guro E. ;

Nesbakken, Arild ;

Skotheim, Rolf I. ;

Lothe, Ragnhild A. .

GUT, 2012, 61 (11) :1560-1567

[3] Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study [J].

Andreyev, HJN ;

Norman, AR ;

Cunningham, D ;

Oates, JR ;

Clarke, PA .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (09) :675-684

[4]

[Anonymous], 2012, SEER Stat Fact Sheets: Cervix Uteri Cancer

[5] Celecoxib for the prevention of colorectal adenomatous polyps [J].

Arber, Nadir ;

Eagle, Craig J. ;

Spicak, Julius ;

Racz, Istvan ;

Dite, Petr ;

Hajer, Jan ;

Zavoral, Miroslav ;

Lechuga, Maria J. ;

Gerletti, Paola ;

Tang, Jie ;

Rosenstein, Rebecca B. ;

Macdonald, Katie ;

Bhadra, Pritha ;

Fowler, Robert ;

Wittes, Janet ;

Zauber, Ann G. ;

Solomon, Scott D. ;

Levin, Bernard .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) :885-895

[6] A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas [J].

Baron, John A. ;

Sandler, Robert S. ;

Bresalier, Robert S. ;

Quan, Hui ;

Riddell, Robert ;

Lanas, Angel ;

Bolognese, James A. ;

Oxenius, Bettina ;

Horgan, Kevin ;

Loftus, Susan ;

Morton, Dion G. .

GASTROENTEROLOGY, 2006, 131 (06) :1674-1682

[7] Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas:: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study [J].

Bazan, V. ;

Agnese, V. ;

Corsale, S. ;

Calo, V. ;

Valerio, M. R. ;

Latteri, M. A. ;

Vieni, S. ;

Grassi, N. ;

Cicero, G. ;

Dardanoni, G. ;

Tomasino, R. M. ;

Colucci, G. ;

Gebbia, N. ;

Russo, Antonio .

ANNALS OF ONCOLOGY, 2005, 16 :50-55

[8] Celecoxib for the prevention of sporadic colorectal adenomas [J].

Bertagnolli, Monica M. ;

Eagle, Craig J. ;

Zauber, Ann G. ;

Redston, Mark ;

Solomon, Scott D. ;

Kim, KyungMann ;

Tang, Jie ;

Rosenstein, Rebecca B. ;

Wittes, Janet ;

Corle, Donald ;

Hess, Timothy M. ;

Woloj, G. Mabel ;

Boisserie, Frederic ;

Anderson, William F. ;

Viner, Jaye L. ;

Bagheri, Donya ;

Burn, John ;

Chung, Daniel C. ;

Dewar, Thomas ;

Foley, T. Raymond ;

Hoffman, Neville ;

Macrae, Finlay ;

Pruitt, Ronald E. ;

Saltzman, John R. ;

Salzberg, Bruce ;

Sylwestrowicz, Thomas ;

Gordon, Gary B. ;

Hawk, Ernest T. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (09) :873-884

[9] A Molecularly Annotated Platform of Patient-Derived Xenografts ("Xenopatients") Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer [J].

Bertotti, Andrea ;

Migliardi, Giorgia ;

Galimi, Francesco ;

Sassi, Francesco ;

Torti, Davide ;

Isella, Claudio ;

Cora, Davide ;

Di Nicolantonio, Federica ;

Buscarino, Michela ;

Petti, Consalvo ;

Ribero, Dario ;

Russolillo, Nadia ;

Muratore, Andrea ;

Massucco, Paolo ;

Pisacane, Alberto ;

Molinaro, Luca ;

Valtorta, Emanuele ;

Sartore-Bianchi, Andrea ;

Risio, Mauro ;

Capussotti, Lorenzo ;

Gambacorta, Marcello ;

Siena, Salvatore ;

Medico, Enzo ;

Sapino, Anna ;

Marsoni, Silvia ;

Comoglio, Paolo M. ;

Bardelli, Alberto ;

Trusolino, Livio .

CANCER DISCOVERY, 2011, 1 (06) :508-523

[10] Neuroendocrine Tumors of the Colon and Rectum: Prognostic Relevance and Comparative Performance of Current Staging Systems [J].

Chagpar, Ryaz ;

Chiang, Yi-Ju ;

Xing, Yan ;

Cormier, Janice N. ;

Feig, Barry W. ;

Rashid, Asif ;

Chang, George J. ;

You, Y. Nancy .

ANNALS OF SURGICAL ONCOLOGY, 2013, 20 (04) :1170-1178

← 1 2 3 4 5 6 7 →