Systemic lupus erythematosus. Target criteria for treatment

被引：2

作者：

Alexander, T. ^{[1
]}

Biesen, R. ^{[1
]}

Jacobi, A. ^{[1
]}

Hoyer, B. ^{[1
]}

Bruns, A. ^{[1
]}

Hiepe, F. ^{[1
]}

机构：

[1] Charite, Med Klin Schwerpunkt Rheumatol & Klin Immunol, D-10117 Berlin, Germany

来源：

ZEITSCHRIFT FUR RHEUMATOLOGIE | 2009年 / 68卷 / 01期

关键词：

Systemic lupus erythematosus (SLE); Target criteria; Biomarker; Auto-antibodies; Controlled clinical trials; DISEASE-ACTIVITY INDEX; SEVERITY INDEX; EXPRESSION; CELLS; RHEUMATOLOGY; ASSOCIATION; RELIABILITY; INSTRUMENT; ANTIBODIES; MARKERS;

D O I：

10.1007/s00393-008-0359-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic lupus erythematosus (SLE) is a chronic systemic intermittent autoimmune disease, which can affect nearly all organ systems. The disease is characterized by the detection of more than 100 different auto-antibodies. For the clinical practice as well as in controlled clinical studies it is absolutely necessary to define target criteria which allow the evaluation of the effectiveness of therapy. Many instruments are available for measuring the activity of the disease, the quality of life, the extent of irreversible damage and the individual manifestation in organs. There are also now various biomarkers to characterize the pathophysiologic aspects, clinical activity, therapeutic effectiveness and prognosis.

引用

页码：23 / +

页数：6

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