Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays

被引：34

作者：

Figueiredo-Gonzalez, M. ^{[1
,2
]}

Reboredo-Rodriguez, P. ^{[1
,3
]}

Gonzalez-Barreiro, C. ^{[1
]}

Simal-Gandara, J. ^{[1
]}

Valentao, P. ^{[2
]}

Carrasco-Pancorbo, A. ^{[4
]}

Andrade, P. B. ^{[2
]}

Cancho-Grande, B. ^{[1
]}

机构：

[1] Univ Vigo, Fac Sci, Analyt & Food Chem Dept, Nutr & Bromatol Grp, Ourense Campus, E-32004 Orense, Spain

[2] Univ Porto, Fac Farm, Dept Quim, REQUIMTE LAQV,Lab Farmacognosia, R Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[3] Univ Politecn Marche, Fac Med, Sez Biochim, Dipartimento Sci Clin Specialist & Odontostomatol, Via Ranieri 65, I-60131 Ancona, Italy

[4] Univ Granada, Dept Analyt Chem, Fac Sci, Ave Fuentenueva S-N, E-18071 Granada, Spain

来源：

FOOD RESEARCH INTERNATIONAL | 2018年 / 106卷

关键词：

Extra-virgin olive oil; Picual cv; Cornicabra cv; Phenols; Neuroprotection; Diabetes mellitus; ANTIOXIDANT ACTIVITY; MONOAMINE-OXIDASE; ALPHA-GLUCOSIDASE; BIOACTIVE COMPOUNDS; INHIBITORY-ACTIVITY; AMYLASE; ANTICHOLINESTERASE; CONSTITUENTS; ENZYMES; FRUIT;

D O I：

10.1016/j.foodres.2018.01.026

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

In this work, phenol-rich extracts from 'Cornicabra' and 'Picual' virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive disorder (MDD) and Parkinson's disease (PD) (monoamine oxidases: hMAO-A and hMAO-B respectively), and diabetes mellitus (DM) (alpha-glucosidase and alpha-amylase). 'Cornicabra' displayed the best inhibitory activity against all enzymes, when compared to 'Picual': BuChE (IC50 = 156 +/- 4 and 308 +/- 33 mg mL(-1)), LOX (IC50 = 26 +/- 0.5 and 37 +/- 3 mg mL(-1)), hMAO-A (IC50 = 20 +/- 2 and 37 +/- 0.2 mg mL-1), hMAO-B (IC50 = 131 +/- 7 and 215 +/- 13 mg mL(-1)) and alpha-glucosidase (IC50 = 154 +/- 17 and 251 +/- 31 mg mL(-1)), respectively. The behaviour observed can be associated with the higher content of secoiridoids, lignans and phenolic acids in 'Cornicabra' EVOO.

引用

页码：558 / 567

页数：10

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