Pertussis toxin modulates microglia and T cell profile to protect experimental autoimmune encephalomyelitis

被引：10
作者：
Yin, Jun-xiang [1 ]
Tang, Zhiwei [1 ]
Gan, Yan [1 ]
Li, Lejun [1 ]
Shi, Fudong [1 ]
Coons, Stephen [2 ]
Shi, Jiong [1 ]
机构：
[1] Barrow Neurol Inst, Dept Neurol, Phoenix, AZ 85013 USA
[2] Barrow Neurol Inst, Dept Neuropathol, Phoenix, AZ 85013 USA
来源：
NEUROPHARMACOLOGY | 2014年 / 81卷
关键词：
Experimental autoimmune; encephalomyelitis; Multiple sclerosis; Pertussis toxin; Myelin oligodendrocyte glycoprotein; Microglia; MULTIPLE-SCLEROSIS; REGULATORY CELLS; MACROPHAGES; MODEL; MICE;
D O I：
10.1016/j.neuropharm.2014.01.027
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Pertussis toxin (PTx) has various effects in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study was designed to explore the protective effects of PTx of different doses and subunits. EAE model was induced with myelin oligodendrocyte glycoprotein (MOG35 55, 200 ug) plus complete Freund's adjuvant in 6-7 week-old female C57BL/6 mice. PTx reduced clinical deficits of EAR by 913%. This reduction in clinical deficits was achieved by attenuating demyelination by 75.5%. Furthermore, PTx reduced the lymphocyte infiltration, deactivated microglia activation and changed T cell profile by increasing T helper (type 1 and 2) and T regulatory cells. (C) 2014 Elsevier Ltd. All rights reserved.
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页码：1 / 5
页数：5
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