Gut feelings: A randomised, triple-blind, placebo-controlled trial of probiotics for depressive symptoms

被引:156
作者
Chahwan, Bahia [1 ]
Kwan, Sophia [2 ]
Isik, Ashling [2 ]
van Hemert, Saskia [3 ]
Burke, Catherine [1 ]
Roberts, Lynette [2 ]
机构
[1] Univ Technol Sydney, Sch Life Sci, POB 123 Broadway, Sydney, NSW 2007, Australia
[2] Univ Technol Sydney, Grad Sch Hlth, Discipline Clin Psychol, Sydney, NSW, Australia
[3] Winclove Probiot, Amsterdam, Netherlands
关键词
Depression; Probiotics; Gut bacteria; Gut-brain axis; Microbiota; Cognitive reactivity; TREATMENT-RESISTANT DEPRESSION; FECAL MICROBIOTA COMPOSITION; ANTIMICROBIAL ACTIVITY; COGNITIVE REACTIVITY; BEHAVIORAL ACTIVATION; TREATMENT RESPONSE; BRAIN; ANXIETY; HEALTH; PSYCHOBIOTICS;
D O I
10.1016/j.jad.2019.04.097
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Depression is the leading cause of disability worldwide; with evidence suggesting that decreased gut barrier function and inflammation are correlated with depressive symptoms. We conducted a clinical trial to determine the effect of consumption of probiotic supplements (Winclove's Ecologic (R) Barrier) on depressive symptoms in a sample of participants with mild to severe depression. Method: 71 participants were randomly allocated to either probiotic or placebo, which was, consumed daily over eight weeks. Pre- and post-intervention measures of symptoms and vulnerability markers of depression as well as gut microbiota composition were compared. Clinical trial participants were also compared on psychological variables and gut microbiota composition to a non-depressed group (n = 20). Results: All clinical trial participants demonstrated improvement in symptoms, suggesting non-specific therapeutic effects associated with weekly monitoring visits. Participants in the probiotic group demonstrated a significantly greater reduction in cognitive reactivity compared with the placebo group, particularly in the mild/moderate subgroup. Probiotics did not significantly alter the microbiota of depressed individuals, however, a significant correlation was found between Ruminococcus gnavus and one depression metric. Limitations: There was a high attrition rate, which may be attributed to weekly monitoring visits. Additionally, modulation of the gut microbiota may need more specific testing to distinguish subtle changes. Conclusions: While microbiota composition was similar between all groups, probiotics did affect a psychological variable associated with susceptibility to depression. Further research is needed to investigate how probiotics can be utilised to modify mental wellbeing, and whether they can act as an adjunct to existing treatments.
引用
收藏
页码:317 / 326
页数:10
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