Folate overproduction in Lactobacillus plantarum WCFS1 causes methotrexate resistance

被引：15
|
作者：
Wegkamp, Arno [1 ,2 ]
de Vos, Willem M. [2 ]
Smid, Eddy J. [1 ,2 ]
机构：
[1] NIZO Food Res, NL-6710 BA Ede, Netherlands
[2] TI Food & Nutr, Wageningen, Netherlands
来源：
FEMS MICROBIOLOGY LETTERS | 2009年 / 297卷 / 02期
关键词：
folate biosynthesis genes; folate overproduction; Lactobacillus plantarum; methotrexate resistance; natural overproduction; LACTOCOCCUS-LACTIS; GROWTH; TRIMETHOPRIM; PROTEIN;
D O I：
10.1111/j.1574-6968.2009.01690.x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Folate overproduction can serve as a mode of resistance against the folate antagonist methotrexate in Lactobacillus plantarum WCFS1. When compared with a wild-type control strain, an engineered high folate-producing strain was found to be insensitive to methotrexate. The growth rate and the viable count of the folate-overproducing L. plantarum strain were not significantly affected by the presence of methotrexate in the growth medium.
引用
收藏
页码：261 / 265
页数：5
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