LONG-TERM LINEZOLID TREATMENT IN A YOUNG CHILD WITH EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS

被引:26
作者
Schaaf, H. Simon [1 ,2 ]
Willemse, Marianne [3 ]
Donald, Peter R. [1 ,2 ]
机构
[1] Univ Stellenbosch, Dept Paediat & Child Hlth, Cape Town, South Africa
[2] Tygerberg Childrens Hosp, Cape Town, South Africa
[3] Prov Govt Western Cape Brooklyn Chest Hosp, Dept Hlth, Cape Town, South Africa
关键词
extensively drug-resistant; tuberculosis; treatment; linezolid; MYCOBACTERIUM-TUBERCULOSIS; EFFICACY;
D O I
10.1097/INF.0b013e31819bc491
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Treatment of extensively drug-resistant tuberculosis (XDR-TB) is a challenge. We describe a Young child with pulmonary XDR-TB who did not respond to all aggressive multidrug-resistant TB treatment regimen, but was cured with linezolid in combination with other reserve antituberculous drugs. No serious adverse events were observed during 19 months of treatment for XDR-TB.
引用
收藏
页码:748 / 750
页数:3
相关论文
共 10 条
[1]   In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs [J].
Alcalá, L ;
Ruiz-Serrano, MJ ;
Turégano, CPF ;
Garcia de Viedma, D ;
Díaz-Infantes, M ;
Marín-Arriaza, M ;
Bouza, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (01) :416-417
[2]   Intravenous linezolid administered orally: A novel desensitization strategy [J].
Cawley, MJ ;
Lipka, O .
PHARMACOTHERAPY, 2006, 26 (04) :563-568
[3]  
Condos Rany, 2008, Chest, V134, P187, DOI 10.1378/chest.07-1988
[4]  
Donald PR, 2001, SCAND J INFECT DIS, V33, P466, DOI 10.1080/00365540152029954
[5]   In vitro activity of linezolid against multidrug-resistant Mycobacterium tuberculosis isolates [J].
Erturan, Z ;
Uzun, M .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2005, 26 (01) :78-80
[6]   Linezolid for the treatment of multidrug-resistant tuberculosis [J].
Fortún, J ;
Martín-Dávila, P ;
Navas, E ;
Pérez-Elías, MJ ;
Cobo, J ;
Tato, M ;
De la Pedrosa, EGG ;
Gómez-Mampaso, E ;
Moreno, S .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (01) :180-185
[7]   Use of linezolid in children [J].
Kaplan, SL .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2002, 21 (09) :870-872
[8]   ANTITUBERCULOSIS ACTIVITY OF CLARITHROMYCIN [J].
LUNAHERRERA, J ;
REDDY, VM ;
DANELUZZI, D ;
GANGADHARAM, PRJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (12) :2692-2695
[9]   Efficacy and tolerability of daily-half dose linezolid in patients with intractable multidrug-resistant tuberculosis [J].
Park, I-Nae ;
Hong, Sang-Bum ;
Oh, Yeon-Mok ;
Kim, Mi-Na ;
Lim, Chae-Man ;
Lee, Sang Do ;
Koh, Younsuck ;
Kim, Woo Sung ;
Kim, Dong Soon ;
Kim, Won Dong ;
Shim, Tae Sun .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (03) :701-704
[10]   Efficacy and safety of linezolid in multidrug resistant tuberculosis (MDR-TB) - a report of ten cases [J].
von der Lippe, B ;
Sandven, P ;
Brubakk, O .
JOURNAL OF INFECTION, 2006, 52 (02) :92-96