Fluoroalkyl-Containing 1,2-Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry

被引：14

作者：

Demchuk, Oleksandr P. ^{[1
,2
]}

Hryshchuk, Oleksandr V. ^{[1
,3
]}

Vashchenko, Bohdan V. ^{[1
,3
]}

Trofymchuk, Serhii A. ^{[1
]}

Melnykov, Kostiantyn P. ^{[1
,3
]}

Skreminskiy, Artem ^{[1
]}

Volochnyuk, Dmitriy M. ^{[1
,2
]}

Grygorenko, Oleksandr O. ^{[1
]}

机构：

[1] Enamine Ltd, Chervonotkatska St 78, UA-02094 Kiev, Ukraine

[2] Natl Acad Sci Ukraine, Inst Organ Chem, Murmanska St 5, UA-02660 Kiev, Ukraine

[3] Taras Shevchenko Natl Univ Kyiv, Volodymyrska St 60, UA-01601 Kiev, Ukraine

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 01期

关键词：

Amines; Building blocks; Carboxylic acids; Cyclobutane; Fluorine; FLUORINATION; ANALOGS; POTENT; ACID; INHIBITORS; DISCOVERY; POLARITY; ROUTE; ALKYL;

D O I：

10.1002/ejoc.202001345

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of previously unavailable 1,2-disubstituted cyclobutane building blocks bearing mono-, di- and trifluoromethyl groups are disclosed. The key steps included deoxofluorination or TMAF-mediated nucleophilic substitution in the appropriate bifunctional cyclobutanes; for the CF3-substituted derivatives, alternative methods based on cyano- or azidotrifluoromethylation of cyclobutene using the Togni reagent II were also proposed. All methods provided trans diastereomers of the target primary amines and carboxylic acids (6 representatives) and were suitable for their multigram preparation. Furthermore, dissociation constants (pK(a)) and lipophilicity (logP) values were measured to evaluate the effect of the fluoroalkyl substituents on acidity/basicity and lipophilicity of the building blocks obtained.

引用

页码：87 / 95

页数：9

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