Increased expression of cardiac phosphatases in patients with end-stage heart failure

被引：212
作者：
Neumann, J
Eschenhagen, T
Jones, LR
Linck, B
Schmitz, W
Scholz, H
Zimmermann, N
机构：
[1] UNIV HAMBURG, HOSP EPPENDORF, ABT ALLGEMEINE PHARMAKOL, D-20246 HAMBURG, GERMANY
[2] KRANNERT CARDIOVASC RES INST, INDIANAPOLIS, IN 46202 USA
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1997年 / 29卷 / 01期
关键词：
phosphatases; human heart failure; protein phosphorylation;
D O I：
10.1006/jmcc.1996.0271
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls. Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure. (C) 1997 Academic Press Limited
引用
收藏
页码：265 / 272
页数：8
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