Role of von Willebrand factor in the angiogenesis of lung adenocarcinoma

被引：6

作者：

Li, Xin ^{[1
,2
]}

Lu, Zhong ^{[1
,3
]}

机构：

[1] Weifang Med Coll, Dept Oncol, Affiliated Hosp, Weifang, Shandong, Peoples R China

[2] Weifang Med Coll, Grad Sch, Weifang 261053, Shandong, Peoples R China

[3] Weifang Med Coll, Dept Oncol, Affiliated Hosp, 2428 Yuhe Rd, Weifang 261053, Shandong, Peoples R China

来源：

ONCOLOGY LETTERS | 2022年 / 23卷 / 06期

关键词：

von Willebrand factor; angiogenesis; lung adenocarcinoma; endothelial cells; FACTOR PROMOTER; FACTOR-VIII; TUMOR; CANCER; EXPRESSION; VEGF; DISEASE; PREDICT; TARGET; CELLS;

D O I：

10.3892/ol.2022.13319

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung adenocarcinoma (LUAD) has a high morbidity and mortality rate worldwide, and its growth and metastasis require angiogenesis. The density of microvessels in LUAD is positively correlated with metastasis and recurrence. Von Willebrand factor (VWF) is a multifunctional glycoprotein in blood plasma. Recent evidence shows that VWF inhibits angiogenesis through regulation of angiopoietin-2 (Ang-2) and integrin alpha v beta 3. LUAD patients exhibit an increase in the plasma VWF/ADAMTS-13 ratio. Gene expression profiles of LUAD tissues indicate that VWF is differentially expressed in LUAD tissues compared to normal tissues. GATA binding protein 3 (GATA3) transcription factor may mediate VWF expression in LUAD. In this review, we summarize the role of VWF in LUAD and its regulatory mechanisms. We also discuss the potential of VWF as a diagnostic indicator and therapeutic target of LUAD.

引用

页数：7

共 72 条

[1] Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex [J].

Barton, William A. ;

Tzvetkova-Robev, Dorothea ;

Miranda, Edward P. ;

Kolev, Momchil V. ;

Rajashankar, Kanagalaghatta R. ;

Himanen, Juha P. ;

Nikolov, Dimitar B. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (06) :524-532

[2] von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans [J].

Bauer, Alexander T. ;

Suckau, Jan ;

Frank, Kathrin ;

Desch, Anna ;

Goertz, Lukas ;

Wagner, Andreas H. ;

Hecker, Markus ;

Goerge, Tobias ;

Umansky, Ludmila ;

Beckhove, Philipp ;

Utikal, Jochen ;

Gorzelanny, Christian ;

Diaz-Valdes, Nancy ;

Umansky, Viktor ;

Schneider, Stefan W. .

BLOOD, 2015, 125 (20) :3153-3163

[3] INTEGRIN ALPHA(V)BETA(3) ANTAGONISTS PROMOTE TUMOR-REGRESSION BY INDUCING APOPTOSIS OF ANGIOGENIC BLOOD-VESSELS [J].

BROOKS, PC ;

MONTGOMERY, AMP ;

ROSENFELD, M ;

REISFELD, RA ;

HU, TH ;

KLIER, G ;

CHERESH, DA .

CELL, 1994, 79 (07) :1157-1164

[4] The impact of von Willebrand factor on factor VIII memory immune responses [J].

Chen, Juan ;

Schroeder, Jocelyn A. ;

Luo, Xiaofeng ;

Shi, Qizhen .

BLOOD ADVANCES, 2017, 1 (19) :1565-1574

[5] Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure [J].

Claus, Ralf A. ;

Bockmeyer, Clemens L. ;

Budde, Ulrich ;

Kentouche, Karim ;

Sossdorf, Maik ;

Hilberg, Thomas ;

Schneppenheim, Reinhart ;

Reinhart, Konrad ;

Bauer, Michael ;

Brunkhorst, Frank M. ;

Loesche, Wolfgang .

THROMBOSIS AND HAEMOSTASIS, 2009, 101 (02) :239-247

[6] Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis [J].

Cossutta, Melissande ;

Darche, Marie ;

Carpenter, Gilles ;

Houppe, Claire ;

Ponzo, Matteo ;

Raineri, Fabio ;

Vallee, Benoit ;

Gilles, Maud-Emmanuelle ;

Villain, Delphine ;

Picard, Emilie ;

Casari, Caterina ;

Denis, Cecile ;

Paques, Michel ;

Courty, Jose ;

Cascone, Ilaria .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2019, 39 (09) :1843-1858

[7] von Willebrand factor multimerization and the polarity of secretory pathways in endothelial cells [J].

da Silva, Mafalda Lopes ;

Cutler, Daniel F. .

BLOOD, 2016, 128 (02) :277-285

[8] Comparative study on the mutational profile of adenocarcinoma and squamous cell carcinoma predominant histologic subtypes in Chinese non-small cell lung cancer patients [J].

Ding, Ying ;

Zhang, Lihua ;

Guo, Lingchuan ;

Wu, Chunyan ;

Zhou, Jianhua ;

Zhou, Yongchun ;

Ma, Jie ;

Li, Xiao ;

Ji, Pan ;

Wang, Ming ;

Zhu, Weidong ;

Shi, Chenxi ;

Li, Sanen ;

Wu, Wei ;

Zhu, Wei ;

Xiao, Desheng ;

Fu, Chunyan ;

He, Qiuyan ;

Sun, Rui ;

Mao, Xinru ;

Lizaso, Analyn ;

Li, Bing ;

Han-Zhang, Han ;

Zhang, Zhihong .

THORACIC CANCER, 2020, 11 (01) :103-112

[9] Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis [J].

Fan, Mengge ;

Wang, Xia ;

Peng, Xun ;

Feng, Shuo ;

Zhao, Junyu ;

Liao, Lin ;

Zhang, Yong ;

Hou, Yinglong ;

Liu, Ju .

BMC CARDIOVASCULAR DISORDERS, 2020, 20 (01)

[10]

Federici AB, 2008, HAEMOPHILIA, V14, P5, DOI 10.1111/j.1365-2516.2007.01610.x

← 1 2 3 4 5 6 7 8 →