Comparison of the effect of lipid A analog E5531 and the lipid a from Escherichia coli on phospholipid membrane properties

被引：0
|
作者：
Asai, Y [1 ]
Watanabe, S
机构：
[1] Eisai & Co Ltd, Formulat Res Lab, Kawashima, Gifu 5016195, Japan
[2] Eisai & Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 3002635, Japan
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 2000年 / 26卷 / 02期
关键词：
fluidity; lipid A; phase transition temperature; phospholipid membrane; size;
D O I：
10.1081/DDC-100100345
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effect of the lipid A analog E5531 on the phospholipid membrane was compared with that of the lipid A from Escherichia coli (EC). E5531 decreased the phase transition temperature of dipalmitoylphosphatidylcholine (DPPC) membrane and increased the fluidity and micropolarity. On the other hand, the effect of EC on the membrane was contradictory. These results suggested that the reason for the difference of biological effects of these two lipid A would be caused by the differences from the effect on the cell membranes.
引用
收藏
页码：199 / 204
页数：6
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