Definition and Risks of Cytokine Release Syndrome in 11 Critically Ill COVID-19 Patients With Pneumonia: Analysis of Disease Characteristics

被引：67
作者：
Wang, Wenjun [1 ]
Liu, Xiaoqing [2 ]
Wu, Sipei [3 ]
Chen, Sibei [2 ]
Li, Yimin [1 ,2 ]
Nong, Lingbo [2 ]
Lie, Puyi [1 ]
Huang, Liyan [1 ]
Cheng, Linling [4 ]
Lin, Yongping [5 ]
He, Jianxing [1 ]
机构：
[1] Guangzhou Med Univ, Guangzhou Resp Hlth Res Inst, State Key Lab Resp Dis, Affiliated Hosp 1, Guangzhou 510120, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Dept Crit Care Med, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
[3] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangzhou, Guangdong, Peoples R China
[4] Guangzhou Eighth Peoples Hosp, Guangzhou, Guangdong, Peoples R China
[5] Guangzhou Med Univ, Lab Dept, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
来源：
JOURNAL OF INFECTIOUS DISEASES | 2020年 / 222卷 / 09期
基金：
中国国家自然科学基金;
关键词：
COVID-19; cytokine release syndrome; IL-6; immunophenotype; severe/critical pneumonia; LUNG INJURY;
D O I：
10.1093/infdis/jiaa387
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of symptoms of CRS in critically ill patients with COVID-19 are important problems. We report a single-center case series of 11 COVID-19 patients with acute respiratory distress syndrome from The First Affiliated Hospital of Guangzhou Medical University in China from 26 January 2020 to 18 February 2020. The termination date of follow-up was 19 February 2020. Eight patients were determined to have characteristics of CRS, including pulmonary inflammation, fever, and dysfunction of nonpulmonary organs. An increase in interleukin-6 in peripheral blood was the highest risk factor and an early indicator of CRS in COVID-19.
引用
收藏
页码：1444 / 1451
页数：8
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