Link between Metabolic Syndrome and Insulin Resistance

被引:221
作者
Gluvic, Zoran [1 ,2 ]
Zaric, Bozidarka [3 ]
Resanovic, Ivana [4 ]
Obradovic, Milan [4 ]
Mitrovic, Aleksandar [5 ]
Radak, Djordje [6 ]
Isenovic, Esma R. [4 ]
机构
[1] Univ Belgrade, Sch Med, Zemun Clin Hosp, Belgrade, Serbia
[2] Univ Belgrade, Sch Med, Belgrade, Serbia
[3] Univ Belgrade, Dept Chem, Inst Chem Technol & Met, Belgrade, Serbia
[4] Univ Belgrade, Inst Nucl Sci Vinca, Lab Radiobiol & Mol Genet, POB 522, Belgrade 11000, Serbia
[5] Serbian Clin Ctr, Clin Vasc & Endovasc Surg, Belgrade, Serbia
[6] Univ Belgrade, Dedinje Cardiovasc Inst, Dept Vasc Surg, Fac Med, Belgrade 11000, Serbia
关键词
Metabolic syndrome; insulin resistance; cardiovascular disease; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; LIPOPROTEIN LDL SUBCLASSES; 3RD NATIONAL-HEALTH; FATTY LIVER-DISEASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; CLINICAL-SIGNIFICANCE; DIABETES-MELLITUS; NITRIC-OXIDE;
D O I
10.2174/1570161114666161007164510
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Metabolic syndrome (MetS) is a leading public health and clinical challenge worldwide. MetS represents a group of interrelated risk factors that predict cardiovascular diseases (CVD) and diabetes mellitus (DM). Its prevalence ranges between 10 and 84%, depending on the geographic region, urban or rural environment, individual demographic characteristics of the population studied (sex, age, racial and ethnic origin), as well as the criteria used to define MetS. Persons with MetS have higher mortality rate when compared with people without MetS, primarily caused by progressive atherosclerosis, accelerated by pro-inflammatory and pro-coagulation components of MetS. Considering the high prevalence of metabolic disorders (glucose metabolism disorder, hypertension, dyslipidaemia, obesity etc.), preventive healthcare should focus on changing lifestyle in order to reduce obesity and increase physical activity. This narrative review considers the available evidence from clinical and experimental studies dealing with MetS, and current treatment options for patients with insulin resistance and MetS.
引用
收藏
页码:30 / 39
页数:10
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