Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis

被引：68

作者：

Thangarajh, M ^{[1
]}

Gomes, A ^{[1
]}

Masterman, T ^{[1
]}

Hillert, J ^{[1
]}

Hjelmström, P ^{[1
]}

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Neurotec Dept, Div Neurol, SE-14186 Stockholm, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 152卷 / 1-2期

关键词：

B lymphocyte; tumor necrosis factor superfamily; autoimmune disorders; multiple sclerosis;

D O I：

10.1016/j.jneuroim.2004.03.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of B cells and antibodies in the pathogenesis of multiple sclerosis (MS) is controversial. We investigated the expression of B-cell-activating factor of the tumor necrosis factor family (BAFF), a protein indispensable for B-cell survival, and of its three receptors in MS patients and controls. BAFF mRNA levels in monocytes, and BAFF-receptor mRNA in B and T cells, were higher in patients than in healthy controls; yet, BAFF protein levels in cerebrospinal fluid and plasma were similar in patients and headache controls. In addition, each MS disease course was associated with a unique expression pattern for all four molecules. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：183 / 190

页数：8

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