A multifunctionalized strategy of indoles to C2-quaternary indolin-3-ones via a TEMPO/Pd-catalyzed cascade process

被引：30

作者：

Deng, Zhongfu ^{[1
]}

Peng, Xiangjun ^{[2
]}

Huang, Panpan ^{[1
]}

Jiang, Lili ^{[1
]}

Ye, Dongnai ^{[1
]}

Liu, Liangxian ^{[1
]}

机构：

[1] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Peoples R China

[2] Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Jiangxi, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 02期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE TRIMERIZATION; ISOQUINOLINE ALKALOIDS; ASYMMETRIC-SYNTHESIS; ACETONITRILE; DERIVATIVES; EFFICIENT; CYANOMETHYLATION; ACTIVATION; NITRILES; ALCOHOLS;

D O I：

10.1039/c6ob02285e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for combinative oxidative homo dimerization and cyanomethylation of free indole derivatives catalysed by TEMPO and Pd(OAc)(2) was demonstrated for the first time. This new methodology is both atom and step efficient and is applicable to a broad scope of substrates, allowing the synthesis of a range of synthetically valuable 2-(2-(1H-indol-3-yl)-3-oxoindolin-2-yl)acetonitriles in moderate to excellent yields.

引用

页码：442 / 448

页数：7

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