Synthesis of 2,3-disubstituted indoles by palladium-mediated coupling of 2-iodoindoles

被引：0

作者：

Tokuyama, H ^{[1
]}

Kaburagi, Y ^{[1
]}

Chen, XQ ^{[1
]}

Fukuyama, T ^{[1
]}

机构：

[1] Univ Tokyo, Japan Sci & Technol Corp, CREST, Grad Sch Pharmaceut Sci,Bunkyo Ku, Tokyo 1130033, Japan

来源：

SYNTHESIS-STUTTGART | 2000年 / 03期

关键词：

2-iodoindole; 2-stannylindole; isonitrile; radical cyclization; palladium-mediated coupling;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Unprotected 2-iodoindoles are synthesized by treatment of 2-stannylindoles with iodine, which in turn are prepared by tin-mediated radical cyclization of 2-alkenylphenylisocyanides. Palladium-catalyzed coupling reactions of N-unprotected 2-iodoindoles with terminal acetylenes, terminal olefins, carbonylation, and the Suzuki coupling reaction with phenyl berate proceed smoothly to furnish the corresponding 2,3-disubstituted indoles in good to excellent yields.

引用

页码：429 / 434

页数：6

共 8 条

[1] A NOVEL TIN-MEDIATED INDOLE SYNTHESIS [J].