Cocaine-associated odor cue re-exposure increases blood oxygenation level dependent signal in memory and reward regions of the maternal rat brain

被引:9
作者
Caffrey, Martha K. [1 ]
Febo, Marcelo [2 ]
机构
[1] Northeastern Univ, Dept Psychol, Boston, MA 02115 USA
[2] Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32611 USA
关键词
Cocaine; Cue; Memory; Pups; Maternal rat; fMRI; CONDITIONED PLACE PREFERENCE; ANTERIOR THALAMIC NUCLEI; SPRAGUE-DAWLEY RATS; EPISODIC MEMORY; HUMAN HIPPOCAMPUS; STRESS RESPONSES; SEX-DIFFERENCES; CORTEX LESIONS; SPATIAL MEMORY; PREOPTIC AREA;
D O I
10.1016/j.drugalcdep.2013.09.032
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: Cue triggered relapse during the postpartum period can negatively impact maternal care. Given the high reward value of pups in maternal rats, we designed an fMRI experiment to test whether offspring presence reduces the neural response to a cocaine associated olfactory cue. Methods: Cocaine conditioned place preference was carried out before pregnancy in the presence of two distinct odors that were paired with cocaine or saline (+Cue and -Cue). The BOLD response to +Cue and -Cue was measured in dams on postpartum days 2-4. Odor cues were delivered to dams in the absence and then the presence of pups. Results: Our data indicate that several limbic and cognitive regions of the maternal rat brain show a greater BOLD signal response to a +Cue versus -Cue. These include dorsal striatum, prelimbic cortex, parietal cortex, habenula, bed nucleus of stria terminalis, lateral septum and the mediodorsal and the anterior thalamic nucleus. Of the aforementioned brain regions, only the parietal cortex of cocaine treated dams showed a significant modulatory effect of pup presence. In this area of the cortex, cocaine exposed maternal rats showed a greater BOLD activation in response to the +Cue in the presence than in the absence of pups. Conclusions: Specific regions of the cocaine exposed maternal rat brain are strongly reactive to drug associated cues. The regions implicated in cue reactivity have been previously reported in clinical imaging work, and previous work supports their role in various motivational and cognitive functions. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:167 / 177
页数:11
相关论文
共 66 条
[1]   The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat [J].
Aggleton, JP ;
Hunt, PR ;
Nagle, S ;
Neave, N .
BEHAVIOURAL BRAIN RESEARCH, 1996, 81 (1-2) :189-198
[2]   Altered neural response of the appetitive emotional system in cocaine addiction: an fMRI Study [J].
Asensio, Samuel ;
Romero, Maria J. ;
Palau, Carmina ;
Sanchez, Amparo ;
Senabre, Isabel ;
Morales, Julia L. ;
Carcelen, Raquel ;
Romero, Francisco J. .
ADDICTION BIOLOGY, 2010, 15 (04) :504-516
[3]   ESTABLISHING AN AFFECTIVE SCALE FOR ODOR PREFERENCES OF INFANT RATS [J].
BROWN, RE ;
WILLNER, JA .
BEHAVIORAL AND NEURAL BIOLOGY, 1983, 38 (02) :251-260
[4]   The human hippocampus and spatial and episodic memory [J].
Burgess, N ;
Maguire, EA ;
O'Keefe, J .
NEURON, 2002, 35 (04) :625-641
[5]   Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory task [J].
Bustamante, Juan-Carlos ;
Barros-Loscertales, Alfonso ;
Ventura-Campos, Noelia ;
Sanjuan, Ana ;
Llopis, Juan-Jose ;
Parcet, Maria-Antonia ;
Avila, Cesar .
BRAIN RESEARCH, 2011, 1375 :111-119
[6]   INTACT VERBAL AND NONVERBAL SHORT-TERM-MEMORY FOLLOWING DAMAGE TO THE HUMAN HIPPOCAMPUS [J].
CAVE, CB ;
SQUIRE, LR .
HIPPOCAMPUS, 1992, 2 (02) :151-164
[7]   Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat [J].
Champagne, FA ;
Chretien, P ;
Stevenson, CW ;
Zhang, TY ;
Gratton, A ;
Meaney, MJ .
JOURNAL OF NEUROSCIENCE, 2004, 24 (17) :4113-4123
[8]   REINSTATEMENT OF COCAINE-REINFORCED RESPONDING IN THE RAT [J].
DEWIT, H ;
STEWART, J .
PSYCHOPHARMACOLOGY, 1981, 75 (02) :134-143
[9]   Declarative memory: Insights from cognitive neurobiology [J].
Eichenbaum, H .
ANNUAL REVIEW OF PSYCHOLOGY, 1997, 48 :547-572
[10]   Acute cocaine alters oxytocin levels in the medial preoptic area and amygdala in lactating rat dams: implications for cocaine-induced changes in maternal behavior and maternal aggression [J].
Elliott, JC ;
Lubin, DA ;
Walker, CH ;
Johns, JM .
NEUROPEPTIDES, 2001, 35 (02) :127-134