Interferon Family Cytokines in Obesity and Insulin Sensitivity

被引：29

作者：

Huang, Ling-Yu ^{[1
]}

Chiu, Chiao-Juno ^{[2
]}

Hsing, Chung-Hsi ^{[3
,4
]}

Hsu, Yu-Hsiang ^{[1
,5
,6
]}

机构：

[1] Natl Cheng Kung Univ, Inst Clin Med, Coll Med, Tainan 701, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Med Res, Taipei 100, Taiwan

[3] Chi Mei Med Ctr, Dept Anesthesiol, Tainan 710, Taiwan

[4] Chi Mei Med Ctr, Dept Med Res, Tainan 710, Taiwan

[5] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Clin Med Res Ctr, Tainan 704, Taiwan

[6] Natl Cheng Kung Univ, Antibody New Drug Res Ctr, Tainan 701, Taiwan

来源：

CELLS | 2022年 / 11卷 / 24期

关键词：

obesity; interferon; insulin resistance; DIET-INDUCED OBESITY; PLASMACYTOID DENDRITIC CELLS; ADIPOSE-TISSUE INFLAMMATION; IFN-GAMMA PRODUCTION; CD4(+) T-CELLS; I INTERFERON; ANTIVIRAL ACTIVITY; GLUCOSE-TRANSPORT; SKELETAL-MUSCLE; HEPATITIS-C;

D O I：

10.3390/cells11244041

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity and its associated complications are global public health concerns. Metabolic disturbances and immune dysregulation cause adipose tissue stress and dysfunction in obese individuals. Immune cell accumulation in the adipose microenvironment is the main cause of insulin resistance and metabolic dysfunction. Infiltrated immune cells, adipocytes, and stromal cells are all involved in the production of proinflammatory cytokines and chemokines in adipose tissues and affect systemic homeostasis. Interferons (IFNs) are a large family of pleiotropic cytokines that play a pivotal role in host antiviral defenses. IFNs are critical immune modulators in response to pathogens, dead cells, and several inflammation-mediated diseases. Several studies have indicated that IFNs are involved in the pathogenesis of obesity. In this review, we discuss the roles of IFN family cytokines in the development of obesity-induced inflammation and insulin resistance.

引用

页数：19

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