Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder

被引：26

作者：

Xu, Xiaohui ^{[1
]}

Mill, Jonathan ^{[1
]}

Sun, Bo ^{[2
]}

Chen, Chih-Ken ^{[3
]}

Huang, Yu-Shu

Wu, Yu-Yu

Asherson, Philip ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England

[2] Kings Coll London, Sch Med, London WC2R 2LS, England

[3] Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung, Taiwan

来源：

BMC PSYCHIATRY | 2009年 / 9卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

DEFICIT/HYPERACTIVITY DISORDER; CANDIDATE GENE; DAT1; REGION; ADHD; DISEQUILIBRIUM; PREVALENCE; HAPLOTYPE; CHILDREN; ALCOHOL;

D O I：

10.1186/1471-244X-9-3

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Attention deficit hyperactivity disorder (ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/SLC6A3) has been considered a good candidate for ADHD. Most association studies with ADHD have investigated the 40-base-pair variable number of tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1. Only few studies have reported association between promoter polymorphisms of the gene and ADHD. Methods: To investigate the association between the polymorphisms -67A/T (rs2975226) and -839C/T (rs2652511) in promoter region of DAT1 in ADHD, two samples of ADHD patients from the UK (n = 197) and Taiwan (n = 212) were genotyped, and analysed using within-family transmission disequilibrium test (TDT). Results: A significant association was found between the T allele of promoter polymorphism -67A/T and ADHD in the Taiwanese population (P = 0.001). There was also evidence of preferential transmission of the T allele of -67A/T polymorphism in combined samples from the UK and Taiwan (P = 0.003). No association was detected between the -839C/T polymorphism and ADHD in either of the two populations. Conclusion: The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.

引用

页数：5

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