Efficacy and safety of oral low-dose glucocorticoids in patients with estrogen-dependent primary osteoarthritis

被引：6

作者：

Canas, Carlos A. ^{[1
]}

Osorio, Carlos J. ^{[2
]}

Coronel, Nicolas ^{[3
]}

Cepeda, Magda C. ^{[4
]}

Izquierdo, Jorge H. ^{[1
]}

Bonilla-Abadia, Fabio ^{[1
]}

机构：

[1] ICESI Univ, Fdn Valle del Lili, Rheumatol Unit, Cali, Colombia

[2] ICESI Univ, Fdn Valle del Lili, Dept Internal Med, Cali, Colombia

[3] CES Univ, Fdn Valle del Lili, Dept Internal Med, Cali, Colombia

[4] Fdn Valle del Lili, Inst Invest Clin, Cali, Colombia

来源：

RHEUMATOLOGY INTERNATIONAL | 2014年 / 34卷 / 05期

关键词：

Primary osteoarthritis; Glucocorticoids; Steroids; Menopause; CLASSIFICATION; CRITERIA; EXPRESSION; CELLS;

D O I：

10.1007/s00296-012-2603-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Estrogen-dependent osteoarthritis (EDPOA) is a disease of perimenopausal-age women. Their manifestations are polyarticular pain with common co-morbidities (carpal tunnel syndrome, insomnia, fatigue, depression, and fibromyalgia). Based on dual role of glucocorticoids, its trophic action on the chondrocyte and its anti-inflammatory effect, we conducted a prospective interventional cohort study where we evaluate the efficacy and safety of oral low-dose GC in one hundred women with EDPOA. The pain intensity, number of tender joints as well as impact in co-morbidities were analyzed. We conclude that the use of low-dose GC in patients with EDPOA can be an effective and a safe therapeutic option.

引用

页码：733 / 735

页数：3

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