CDCA5, Transcribed by E2F1, Promotes Oncogenesis by Enhancing Cell Proliferation and Inhibiting Apoptosis via the AKT Pathway in Hepatocellular Carcinoma

被引：56

作者：

Chen, Hao ^{[1
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Chen, Jun ^{[1
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Zhao, Long ^{[1
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Song, Wenfeng ^{[1
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Xuan, Zefeng ^{[1
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Chen, Jian ^{[1
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Li, Zequn ^{[1
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Song, Guangyuan ^{[1
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Hong, Liangjie ^{[1
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Song, Penghong ^{[1
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Zheng, Shusen ^{[1
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机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Surg,Div Hepatobiliary & Pancreat Surg, Hangzhou 310003, Zhejiang, Peoples R China

[2] CAMS, NHCPRC Key Lab Combined Multiorgan Transplantat, Hangzhou 310003, Zhejiang, Peoples R China

[3] CAMS, Key Lab Diag & Treatment Organ Transplantat, Hangzhou 310003, Zhejiang, Peoples R China

[4] Key Lab Organ Transplantat, Hangzhou 310003, Zhejiang, Peoples R China

[5] Collaborat Innovat Ctr Diag Treatment Infect Dis, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF CANCER | 2019年 / 10卷 / 08期

基金：

中国国家自然科学基金; 国家自然科学基金重大项目;

关键词：

hepatocellular carcinoma; CDCA5; proliferation; apoptosis; E2F1; AKT; SISTER-CHROMATID COHESION; UP-REGULATION; C-MYC; CANCER; PHOSPHORYLATION; SURVIVAL; DIVISION; INVASION; SORORIN;

D O I：

10.7150/jca.28809

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell division cycle associated 5 (CDCA5) is an important element for the interaction between cohesin and chromatin in interphase. It is abnormally expressed in many types of cancer and works as an indicator of poor prognosis, but little is known about its activity in hepatocellular carcinoma (HCC). In the present study, we found that the expression of CDCA5 was upregulated in HCC tissues compared to paracancerous tissues and had a negative correlation with patient survival. Cell proliferation and tumorigenesis were inhibited and cell apoptosis was induced with the knockdown of CDCA5, suggesting an oncogenic role of CDCA5 in liver cancer. Luciferase reporter assay and chromatin immunoprecipitation showed that CDCA5 was transcribed by E2F1. Furthermore, we confirmed that CDCA5 interrupted cell behavior via the AKT pathway. These findings demonstrated that CDCA5 plays an important role in HCC progression.

引用

页码：1846 / 1854

页数：9

共 31 条

[1] Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor [J].