Oxidative Stress in Parkinson's Disease: Potential Benefits of Antioxidant Supplementation

被引：97

作者：

Percario, Sandro ^{[1
]}

da Silva Barbosa, Aline ^{[1
]}

Varela, Everton Luiz Pompeu ^{[1
]}

Gomes, Antonio Rafael Quadros ^{[1
]}

Ferreira, Michelli Erica Souza ^{[1
]}

de Nazare Araujo Moreira, Thayana ^{[1
]}

Dolabela, Maria Fani ^{[2
]}

机构：

[1] Fed Univ Para, Inst Biol Sci, Oxidat Stress Res Lab, Ave Augusto Correa 01, BR-66075110 Belem, Para, Brazil

[2] Fed Univ Para, Inst Hlth Sci, Ave Augusto Correa 01, BR-66075110 Belem, Para, Brazil

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2020年 / 2020卷

关键词：

NITRIC-OXIDE SYNTHASE; MITOCHONDRIAL COMPLEX-I; ALPHA-LIPOIC ACID; NIGROSTRIATAL DOPAMINERGIC-NEURONS; 6-HYDROXYDOPAMINE-LESIONED RAT MODEL; ROTENONE-INDUCED PARKINSONISM; SERUM URATE LEVEL; MOUSE MODEL; VITAMIN-E; L-DOPA;

D O I：

10.1155/2020/2360872

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age and has become increasingly more common with advances in age. The number of individuals older than 60 years has been increasing in modern societies, as well as life expectancy in developing countries; therefore, PD may pose an impact on the economic, social, and health structures of these countries. Oxidative stress is highlighted as an important factor in the genesis of PD, involving several enzymes and signaling molecules in the underlying mechanisms of the disease. This review presents updated data on the involvement of oxidative stress in the disease, as well as the use of antioxidant supplements in its therapy.

引用

页数：23

共 285 条

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