DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children

被引：67

作者：

Milanese, Michele ^{[1
]}

Segat, Ludovica

Pontillo, Alessandra

Arraes, Luiz Claudio

de Lima Filho, Jos Luiz

Crovella, Sergio

机构：

[1] Univ Trieste, Dept Dev & Reprod Sci, Trieste, Italy

[2] Inst Materno Infantil Pernambuco, Recife, PE, Brazil

[3] Univ Fed Pernambuco, Lab Imunopatol Keizo Azami, Recife, PE, Brazil

来源：

AIDS | 2006年 / 20卷 / 12期

关键词：

D O I：

10.1097/01.aids.0000238417.05819.40

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In our study we analysed three single nucleotide polymorphisms (SNPs) in the 5' untranslated region (UTR) of the DEFB1 gene, namely -52(G/A) -44(C/G) and -20(G/A), in three groups of north-eastern Brazilian children in order to assess their role in HIV-1 infection. Our results allowed us to hypothesize that the SNPs located in the 5'UTR of the DEFB1 gene can be employed as a marker of risk for HIV-1 infection.

引用

页码：1673 / 1675

页数：3

共 8 条

[1] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[2] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[3] A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children [J].

Braida, L ;

Boniotto, M ;

Pontillo, A ;

Tovo, PA ;

Amoroso, A ;

Crovella, S .

AIDS, 2004, 18 (11) :1598-1600

[4] Single-nucleotide polymorphisms and haplotype analysis in β-defensin genes in different ethnic populations [J].

Jurevic, RJ ;

Chrisman, P ;

Mancl, L ;

Livingston, R ;

Dale, BA .

GENETIC TESTING, 2002, 6 (04) :261-269

[5] DEFENSINS - A FAMILY OF ANTIMICROBIAL AND CYTOTOXIC PEPTIDES [J].

KAGAN, BL ;

GANZ, T ;

LEHRER, RI .

TOXICOLOGY, 1994, 87 (1-3) :131-149

[6] Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins [J].

Leikina, E ;

Delanoe-Ayari, H ;

Melikov, K ;

Cho, MS ;

Chen, A ;

Waring, AJ ;

Wang, W ;

Xie, YM ;

Loo, JA ;

Lehrer, RI ;

Chernomordik, LV .

NATURE IMMUNOLOGY, 2005, 6 (10) :995-1001

[7]

Quiñones-Mateu ME, 2003, AIDS, V17, pF39, DOI [10.1097/01.aids.0000096878.73209.4f, 10.1097/00002030-200311070-00001]

[8] Human β-defensins suppress human immunodeficiency virus infection:: Potential role in mucosal protection [J].

Sun, LL ;

Finnegan, CM ;

Kish-Catalone, T ;

Blumenthal, R ;

Garzino-Demo, P ;

Maggiore, GML ;

Berrone, S ;

Kleinman, C ;

Wu, ZB ;

Abdelwahab, S ;

Lu, WY ;

Garzino-Demo, A .

JOURNAL OF VIROLOGY, 2005, 79 (22) :14318-14329

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