The antitumor activity of naturally occurring chromones: A review

被引：88
作者：
Duan, Ya-di [1 ]
Jiang, Yan-yan [1 ]
Guo, Feng-xia [1 ]
Chen, Lu-xiao [1 ]
Xu, Lu-lu [1 ]
Zhang, Wei [1 ]
Liu, Bin [1 ]
机构：
[1] Beijing Univ Chinese Med, Beijing 102488, Peoples R China
来源：
FITOTERAPIA | 2019年 / 135卷
基金：
中国国家自然科学基金;
关键词：
Chromone; Antitumor activity; Mechanism; Cytotoxicity; DIHYDROTHIOPHENE-CONDENSED CHROMONES; ANGELICA-JAPONICA ROOTS; CD4(+) T-CELLS; 2-(2-PHENYLETHYL)CHROMONE DERIVATIVES; CHEMICAL-CONSTITUENTS; INHIBITORY COMPOUNDS; GENE-TRANSFER; A-D; FUNGUS; CANCER;
D O I：
10.1016/j.fitote.2019.04.012
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chromones are a group of compounds widely distributed in nature with wide range of biological activities, including antitumor, antimicrobial, antiviral, anti-inflammatory, antioxidant, and so on. This review mainly summarizes chromones with antitumor activity in nature and classifies them into three groups, including chromanones, simple chromones, and fused chromones. They exhibit antitumor activity through broad range of mechanisms including cytotoxicity, antimetastasis, antiangiogenesis, chemoprevention, immune regulation, etc.
引用
收藏
页码：114 / 129
页数：16
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