BiP binding keeps ATF6 at bay

被引：63

作者：

Sommer, T ^{[1
]}

Jarosch, E ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

来源：

DEVELOPMENTAL CELL | 2002年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1534-5807(02)00210-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A study by Shen et al. in this issue of Developmental Cell shows that transport to the Golgi complex and subsequent proteolytic activation of the stress-regulated transcription factor ATF6 is initiated by the dissociation of the ER chaperone BiP from ATF6. This demonstrates that BiP is a key element in sensing the folding capacity within the ER and provides mechanistic insights on how the activation of membrane-bound transcription factors can be regulated.

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页码：1 / 2

页数：2

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