Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline-Malononitrile AIEgen and Thin-Layer Molybdenum Disulfide

被引：19

作者：

Dou, Wei-Tao ^{[1
,2
]}

Zhang, Jing-Jing ^{[3
,4
]}

Li, Qiang ^{[1
,2
]}

Guo, Zhiqian ^{[1
,2
]}

Zhu, Weihong ^{[1
,2
]}

Chen, Guo-Rong ^{[1
,2
]}

Zhang, Hai-Yan ^{[3
,4
]}

He, Xiao-Peng ^{[1
,2
]}

机构：

[1] East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China

[4] Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China

来源：

CHEMBIOCHEM | 2019年 / 20卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; fluorescence; imaging agents; peptides; self-assembly; GRAPHENE OXIDE; AGGREGATION; FIBRILLATION;

D O I：

10.1002/cbic.201800508

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sensitive imaging of amyloid-beta (A beta) peptides is important for the timely detection of neurodegenerative diseases, such as Alzheimer's disease (AD). Although clinically the diagnosis of AD relies on the use of radiolabeled imaging reagents, herein we report the simple construction of a "flat ensemble" formed between a quinoline-malononitrile AIEgen (EDS) and thin-layer molybdenum disulfide (2D MoS2) for the sensitive detection of A beta by means of fluorescence-based techniques. Self-assembly between EDS and 2D MoS2 in aqueous buffer solution produces the flat ensemble, and the subsequent interaction of the material ensemble with oligomeric and aggregated A beta peptides leads to up to 19-fold enhanced fluorescence of EDS. The ensemble is also applicable for staining A beta aggregates in vivo.

引用

页码：1856 / 1860

页数：5

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